3W6I

Crystal structure of 19F probe-labeled hCAI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004064	molecular_function	arylesterase activity
A	0004089	molecular_function	carbonate dehydratase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0009750	biological_process	response to fructose
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0018820	molecular_function	cyanamide hydratase activity
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
E	0004064	molecular_function	arylesterase activity
E	0004089	molecular_function	carbonate dehydratase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008270	molecular_function	zinc ion binding
E	0009750	biological_process	response to fructose
E	0016829	molecular_function	lyase activity
E	0016836	molecular_function	hydro-lyase activity
E	0018820	molecular_function	cyanamide hydratase activity
E	0046872	molecular_function	metal ion binding
E	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLB A 301

Chain	Residue
A	VAL62
A	HIS67
A	ASN69
A	PHE91
A	GLN92
A	HIS94
A	ALA135
A	LEU198

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	HIS96
A	HIS119
A	THR199
A	HOH463
A	HIS94

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLB E 301

Chain	Residue
A	ALA132
E	VAL62
E	HIS67
E	ASN69
E	PHE91
E	GLN92
E	HIS94
E	ALA121
E	ALA135
E	LEU198

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 302

Chain	Residue
E	HIS94
E	HIS96
E	HIS119
E	THR199
E	HOH460

---

Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdgvkYsaELHVA

Chain	Residue	Details
A	SER105-ALA121

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"description":"in variant Michigan-1","evidences":[{"source":"PubMed","id":"12009884","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12009884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15299369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16506782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16870440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17314045","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17407288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6430186","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7932756","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"804171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8057362","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8057362","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---