Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3W5A

Crystal structure of the calcium pump and sarcolipin from rabbit fast twitch skeletal muscle in the E1.Mg2+ state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005215	molecular_function	transporter activity
A	0005388	molecular_function	P-type calcium transporter activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016887	molecular_function	ATP hydrolysis activity
A	0031448	biological_process	positive regulation of fast-twitch skeletal muscle fiber contraction
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0046872	molecular_function	metal ion binding
A	0070588	biological_process	calcium ion transmembrane transport
A	0106134	biological_process	positive regulation of cardiac muscle cell contraction
A	1901896	biological_process	positive regulation of ATPase-coupled calcium transmembrane transporter activity
A	1902082	biological_process	positive regulation of calcium ion import into sarcoplasmic reticulum
A	1990036	biological_process	calcium ion import into sarcoplasmic reticulum
B	0000166	molecular_function	nucleotide binding
B	0005215	molecular_function	transporter activity
B	0005388	molecular_function	P-type calcium transporter activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0016887	molecular_function	ATP hydrolysis activity
B	0031448	biological_process	positive regulation of fast-twitch skeletal muscle fiber contraction
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0046872	molecular_function	metal ion binding
B	0070588	biological_process	calcium ion transmembrane transport
B	0106134	biological_process	positive regulation of cardiac muscle cell contraction
B	1901896	biological_process	positive regulation of ATPase-coupled calcium transmembrane transporter activity
B	1902082	biological_process	positive regulation of calcium ion import into sarcoplasmic reticulum
B	1990036	biological_process	calcium ion import into sarcoplasmic reticulum
C	0004857	molecular_function	enzyme inhibitor activity
C	0005515	molecular_function	protein binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
C	0016020	cellular_component	membrane
C	0016529	cellular_component	sarcoplasmic reticulum
C	0030234	molecular_function	enzyme regulator activity
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0043242	biological_process	negative regulation of protein-containing complex disassembly
C	0051117	molecular_function	ATPase binding
C	0051924	biological_process	regulation of calcium ion transport
C	0070296	biological_process	sarcoplasmic reticulum calcium ion transport
C	0090281	biological_process	negative regulation of calcium ion import
C	1901077	biological_process	regulation of relaxation of muscle
C	1901881	biological_process	positive regulation of protein depolymerization
C	1901894	biological_process	regulation of ATPase-coupled calcium transmembrane transporter activity
C	1901895	biological_process	negative regulation of ATPase-coupled calcium transmembrane transporter activity
C	1902081	biological_process	negative regulation of calcium ion import into sarcoplasmic reticulum

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TM1 A 1001

Chain	Residue
A	THR353
A	ARG678
A	VAL679
A	GLU680
A	HOH4006
A	PHE487
A	ARG489
A	LYS492
A	MET494
A	LYS515
A	ARG560
A	THR625
A	GLY626

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PTY A 1002

Chain	Residue
A	SER830
A	GLY831
A	TRP832
A	PHE835
A	LEU992

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PTY A 1003

Chain	Residue
A	ARG989
A	ASN990

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 1004

Chain	Residue
A	ALA305
A	ASN768
A	GLU771
A	ASN796
A	ASP800
A	HOH4001
A	HOH4002

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1005

Chain	Residue
A	HOH4003
A	HOH4004
A	HOH4005
A	HOH4006

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 1006

Chain	Residue
A	LEU711
A	LYS712
A	ALA714
A	GLU732

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TM1 B 1001

Chain	Residue
B	THR353
B	PHE487
B	ARG489
B	MET494
B	LYS515
B	ARG560
B	GLY626
B	ARG678
B	VAL679
B	MG1006

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PTY B 1002

Chain	Residue
B	SER830
B	GLY831
B	TRP832

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PTY B 1003

Chain	Residue
B	MET923
B	GLU982
B	PHE986
B	ARG989
B	ASN990

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PTY B 1004

Chain	Residue
B	ILE274
B	PHE776
B	ALA779
B	ALA780
B	PHE986

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 1005

Chain	Residue
B	ALA305
B	ASN768
B	GLU771
B	ASN796
B	ASP800
B	HOH4001
B	HOH4002

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 1006

Chain	Residue
B	TM11001
B	HOH4003
B	HOH4004
B	HOH4005
B	HOH4006

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 1007

Chain	Residue
B	LEU711
B	LYS712
B	ALA714
B	GLU732

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP351-THR357

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N5K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1326
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	216
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	40
Details	Region: {"description":"Interaction with PLN","evidences":[{"source":"PubMed","id":"10551848","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23996003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	22
Details	Region: {"description":"Interaction with PLN","evidences":[{"source":"PubMed","id":"23996003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18075584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C8K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C8K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64578","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64578","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	30
Details	Peptide: {"description":"Sarcolipin","featureId":"PRO_0000045900"}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	6
Details	Topological domain: {"description":"Cytoplasmic"}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	18
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	4
Details	Topological domain: {"description":"Lumenal"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 849

Chain	Residue	Details
A	THR355	covalent catalysis
A	ASP707	metal ligand
A	LEU711	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 849

Chain	Residue	Details
B	THR355	covalent catalysis
B	ASP707	metal ligand
B	LEU711	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)