Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3W59

Crystal structure of Galectin-1 in the lactose-unbound state(P212121)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006915	biological_process	apoptotic process
A	0007165	biological_process	signal transduction
A	0030246	molecular_function	carbohydrate binding
A	0030395	molecular_function	lactose binding
A	0031012	cellular_component	extracellular matrix
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043236	molecular_function	laminin binding
A	0046598	biological_process	positive regulation of viral entry into host cell
A	0048018	molecular_function	receptor ligand activity
A	0050729	biological_process	positive regulation of inflammatory response
A	0070062	cellular_component	extracellular exosome
A	0098609	biological_process	cell-cell adhesion
A	2000329	biological_process	negative regulation of T-helper 17 cell lineage commitment
A	2001200	biological_process	positive regulation of dendritic cell differentiation
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006915	biological_process	apoptotic process
B	0007165	biological_process	signal transduction
B	0030246	molecular_function	carbohydrate binding
B	0030395	molecular_function	lactose binding
B	0031012	cellular_component	extracellular matrix
B	0042981	biological_process	regulation of apoptotic process
B	0043065	biological_process	positive regulation of apoptotic process
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0043236	molecular_function	laminin binding
B	0046598	biological_process	positive regulation of viral entry into host cell
B	0048018	molecular_function	receptor ligand activity
B	0050729	biological_process	positive regulation of inflammatory response
B	0070062	cellular_component	extracellular exosome
B	0098609	biological_process	cell-cell adhesion
B	2000329	biological_process	negative regulation of T-helper 17 cell lineage commitment
B	2001200	biological_process	positive regulation of dendritic cell differentiation
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006915	biological_process	apoptotic process
C	0007165	biological_process	signal transduction
C	0030246	molecular_function	carbohydrate binding
C	0030395	molecular_function	lactose binding
C	0031012	cellular_component	extracellular matrix
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043236	molecular_function	laminin binding
C	0046598	biological_process	positive regulation of viral entry into host cell
C	0048018	molecular_function	receptor ligand activity
C	0050729	biological_process	positive regulation of inflammatory response
C	0070062	cellular_component	extracellular exosome
C	0098609	biological_process	cell-cell adhesion
C	2000329	biological_process	negative regulation of T-helper 17 cell lineage commitment
C	2001200	biological_process	positive regulation of dendritic cell differentiation
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006915	biological_process	apoptotic process
D	0007165	biological_process	signal transduction
D	0030246	molecular_function	carbohydrate binding
D	0030395	molecular_function	lactose binding
D	0031012	cellular_component	extracellular matrix
D	0042981	biological_process	regulation of apoptotic process
D	0043065	biological_process	positive regulation of apoptotic process
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043236	molecular_function	laminin binding
D	0046598	biological_process	positive regulation of viral entry into host cell
D	0048018	molecular_function	receptor ligand activity
D	0050729	biological_process	positive regulation of inflammatory response
D	0070062	cellular_component	extracellular exosome
D	0098609	biological_process	cell-cell adhesion
D	2000329	biological_process	negative regulation of T-helper 17 cell lineage commitment
D	2001200	biological_process	positive regulation of dendritic cell differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	LYS28
A	HIS52
A	HOH323

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME A 202

Chain	Residue
A	GLU86
A	CYS88
A	LEU100
A	PRO101
A	HOH375

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 203

Chain	Residue
A	ARG20
A	CYS130
A	ALA132
A	ARG18

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 204

Chain	Residue
A	ASP92
A	ALA94
A	ASN95
A	LYS107
D	SER83
D	VAL84

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 205

Chain	Residue
A	ARG48
A	ASP54
A	GLU71
A	ARG73
B	THR70
B	ARG111
B	HOH306
B	HOH324

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME B 201

Chain	Residue
A	GLY103
B	GLU86
B	CYS88
B	LEU100
B	PRO101
B	HOH345

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 201

Chain	Residue
B	ASP92
B	ASN95
B	LYS107
B	HOH302
B	HOH364
C	ARG20
C	HOH375

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 202

Chain	Residue
C	ASP92
C	ALA94
C	ASN95
C	LYS107
D	ASP54

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 201

Chain	Residue
A	LYS127
D	ASP92
D	ASN95
D	LYS107
D	HOH313

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	393
Details	Domain: {"description":"Galectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00639","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P16045","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P16045","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)