Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3W3A

Crystal structure of V1-ATPase at 3.9 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0006754	biological_process	ATP biosynthetic process
A	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0006754	biological_process	ATP biosynthetic process
B	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006754	biological_process	ATP biosynthetic process
C	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006754	biological_process	ATP biosynthetic process
D	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006754	biological_process	ATP biosynthetic process
E	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0006754	biological_process	ATP biosynthetic process
F	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005524	molecular_function	ATP binding
G	0006754	biological_process	ATP biosynthetic process
G	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005524	molecular_function	ATP binding
H	0006754	biological_process	ATP biosynthetic process
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0006754	biological_process	ATP biosynthetic process
I	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0046034	biological_process	ATP metabolic process
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0006754	biological_process	ATP biosynthetic process
J	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
J	0045259	cellular_component	proton-transporting ATP synthase complex
J	0046034	biological_process	ATP metabolic process
J	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0006754	biological_process	ATP biosynthetic process
K	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
K	0045259	cellular_component	proton-transporting ATP synthase complex
K	0046034	biological_process	ATP metabolic process
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0006754	biological_process	ATP biosynthetic process
L	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
L	0046034	biological_process	ATP metabolic process
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0006754	biological_process	ATP biosynthetic process
M	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
M	0046034	biological_process	ATP metabolic process
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0006754	biological_process	ATP biosynthetic process
N	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
N	0046034	biological_process	ATP metabolic process
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0005524	molecular_function	ATP binding
O	0006754	biological_process	ATP biosynthetic process
O	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0005524	molecular_function	ATP binding
P	0006754	biological_process	ATP biosynthetic process
P	0034220	biological_process	monoatomic ion transmembrane transport
P	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP A 600

Chain	Residue
A	PRO229
F	ARG360
A	GLY231
A	SER232
A	GLY233
A	LYS234
A	THR235
A	VAL236
A	GLU261
A	PHE419

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP C 600

Chain	Residue
C	PHE230
C	GLY231
C	SER232
C	GLY233
C	LYS234
C	THR235
C	VAL236
C	THR237
C	GLU261
E	GLY330
E	TYR331
E	ARG360
E	ASN363

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP I 600

Chain	Residue
I	PRO229
I	GLY231
I	SER232
I	GLY233
I	LYS234
I	THR235
I	VAL236
I	GLU261
I	PHE419
N	TYR331
N	SER359
N	ARG360

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP K 600

Chain	Residue
K	PHE230
K	GLY231
K	SER232
K	GLY233
K	LYS234
K	THR235
K	VAL236
K	THR237
M	ARG360
M	ASN363

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPIDPLPSLS

Chain	Residue	Details
D	PRO350-SER359
A	PRO420-SER429

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLY228
B	GLY228
C	GLY228
I	GLY228
J	GLY228
K	GLY228

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)