3W0F

Crystal structure of mouse Endonuclease VIII-LIKE 3 (mNEIL3)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0008270	molecular_function	zinc ion binding
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0019104	molecular_function	DNA N-glycosylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	CYS255
A	CYS258
A	CYS277
A	CYS280

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 302

Chain	Residue
A	ARG67
A	GLY76
A	VAL77

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 303

Chain	Residue
A	SER244

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 305

Chain	Residue
A	ARG17

---

Functional Information from PROSITE/UniProt

site_id	PS01242
Number of Residues	27
Details	ZF_FPG_1 Zinc finger FPG-type signature. Cdq..CHskItvcrfgens..RMtyFCphCQ

Chain	Residue	Details
A	CYS255-GLN281

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Zinc finger: {"description":"FPG-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00391","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Schiff-base intermediate with DNA; via amino nitrogen","evidences":[{"source":"PubMed","id":"20185759","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for monofunctional glycosylase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Required for glycosylase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---