3VWD
Crystal structure of alpha-tubulin acetyltransferase domain of human Mec-17 in complex with acetoacetyl-CoA (P21212 form)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE ACO A 201 |
| Chain | Residue |
| A | LYS56 |
| A | HIS133 |
| A | GLY134 |
| A | GLY136 |
| A | ARG137 |
| A | ASP157 |
| A | ARG158 |
| A | SER160 |
| A | LYS162 |
| A | LYS165 |
| A | PHE166 |
| A | GLN58 |
| A | LYS169 |
| A | HIS170 |
| A | CL202 |
| A | HOH301 |
| A | HOH307 |
| A | HOH308 |
| A | HOH312 |
| A | HOH338 |
| A | HOH346 |
| A | HOH349 |
| A | ILE121 |
| A | HOH355 |
| A | HOH395 |
| A | HOH398 |
| A | HOH449 |
| A | HOH506 |
| A | ASP123 |
| A | PHE124 |
| A | TYR125 |
| A | ILE126 |
| A | GLN131 |
| A | ARG132 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL A 202 |
| Chain | Residue |
| A | ALA57 |
| A | GLU128 |
| A | GLN131 |
| A | LYS162 |
| A | LYS162 |
| A | ACO201 |
| A | HOH303 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 203 |
| Chain | Residue |
| A | ARG69 |
| A | MET70 |
| A | HIS75 |
| A | LYS98 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 204 |
| Chain | Residue |
| A | GLY188 |
| A | PHE189 |
| A | PHE190 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 205 |
| Chain | Residue |
| A | ARG23 |
| A | VAL116 |
| A | PHE189 |
| A | PHE190 |
| A | HIS192 |
| A | GLN193 |
| A | HOH344 |
| A | HOH386 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03130","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23071318","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24906155","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Crucial for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_03130","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071318","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q8K341","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03130","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
