3VWD
Crystal structure of alpha-tubulin acetyltransferase domain of human Mec-17 in complex with acetoacetyl-CoA (P21212 form)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE ACO A 201 |
| Chain | Residue |
| A | LYS56 |
| A | HIS133 |
| A | GLY134 |
| A | GLY136 |
| A | ARG137 |
| A | ASP157 |
| A | ARG158 |
| A | SER160 |
| A | LYS162 |
| A | LYS165 |
| A | PHE166 |
| A | GLN58 |
| A | LYS169 |
| A | HIS170 |
| A | CL202 |
| A | HOH301 |
| A | HOH307 |
| A | HOH308 |
| A | HOH312 |
| A | HOH338 |
| A | HOH346 |
| A | HOH349 |
| A | ILE121 |
| A | HOH355 |
| A | HOH395 |
| A | HOH398 |
| A | HOH449 |
| A | HOH506 |
| A | ASP123 |
| A | PHE124 |
| A | TYR125 |
| A | ILE126 |
| A | GLN131 |
| A | ARG132 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL A 202 |
| Chain | Residue |
| A | ALA57 |
| A | GLU128 |
| A | GLN131 |
| A | LYS162 |
| A | LYS162 |
| A | ACO201 |
| A | HOH303 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 203 |
| Chain | Residue |
| A | ARG69 |
| A | MET70 |
| A | HIS75 |
| A | LYS98 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 204 |
| Chain | Residue |
| A | GLY188 |
| A | PHE189 |
| A | PHE190 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 205 |
| Chain | Residue |
| A | ARG23 |
| A | VAL116 |
| A | PHE189 |
| A | PHE190 |
| A | HIS192 |
| A | GLN193 |
| A | HOH344 |
| A | HOH386 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:23071314, ECO:0000269|PubMed:23071318, ECO:0000269|PubMed:24906155 |
| Chain | Residue | Details |
| A | PHE124 | |
| A | SER160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Crucial for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:23071318 |
| Chain | Residue | Details |
| A | GLN58 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000250|UniProtKB:Q8K341, ECO:0000255|HAMAP-Rule:MF_03130 |
| Chain | Residue | Details |
| A | LYS56 | |
| A | LYS146 |
