3VVA

Crystal structure of cyanide-insensitive alternative oxidase from Trypanosoma brucei with ascofuranone derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0008199	molecular_function	ferric iron binding
A	0009916	molecular_function	alternative oxidase activity
A	0010230	biological_process	alternative respiration
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0008199	molecular_function	ferric iron binding
B	0009916	molecular_function	alternative oxidase activity
B	0010230	biological_process	alternative respiration
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0008199	molecular_function	ferric iron binding
C	0009916	molecular_function	alternative oxidase activity
C	0010230	biological_process	alternative respiration
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0008199	molecular_function	ferric iron binding
D	0009916	molecular_function	alternative oxidase activity
D	0010230	biological_process	alternative respiration
D	0016491	molecular_function	oxidoreductase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 501

Chain	Residue
A	GLU123
A	GLU162
A	HIS165
A	GLU266
A	OH503

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE A 502

Chain	Residue
A	GLU162
A	GLU213
A	GLU266
A	OH503

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OH A 503

Chain	Residue
A	GLU123
A	GLU162
A	GLU266
A	FE501
A	FE502
A	CHW504

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CHW A 504

Chain	Residue
A	CYS95
A	ARG96
A	PHE99
A	ARG118
A	PHE121
A	LEU122
A	LEU212
A	GLU215
A	THR219
A	OH503

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE B 501

Chain	Residue
B	GLU123
B	GLU162
B	HIS165
B	GLU266
B	FE502
B	OH503

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE B 502

Chain	Residue
B	GLU162
B	GLU213
B	GLU266
B	FE501
B	OH503

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OH B 503

Chain	Residue
B	GLU123
B	ALA126
B	GLU162
B	GLU266
B	FE501
B	FE502
B	CHW504

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CHW B 504

Chain	Residue
B	CYS95
B	ARG96
B	PHE99
B	ARG118
B	CYS119
B	LEU122
B	GLU123
B	VAL125
B	MET190
B	LEU212
B	ALA216
B	THR219
B	OH503

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE C 501

Chain	Residue
C	GLU123
C	GLU162
C	HIS165
C	GLU266
C	FE502
C	OH503

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE C 502

Chain	Residue
C	GLU162
C	GLU213
C	GLU266
C	FE501
C	OH503

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OH C 503

Chain	Residue
C	GLU123
C	ALA126
C	GLU162
C	GLU266
C	FE501
C	FE502
C	CHW504

---

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CHW C 504

Chain	Residue
C	ARG96
C	PHE99
C	ARG118
C	PHE121
C	LEU122
C	LEU212
C	GLU213
C	GLU215
C	ALA216
C	THR219
C	OH503

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE D 501

Chain	Residue
D	GLU123
D	GLU162
D	HIS165
D	GLU266
D	FE502
D	OH503

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE D 502

Chain	Residue
D	GLU162
D	GLU213
D	GLU266
D	FE501
D	OH503

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OH D 503

Chain	Residue
D	FE501
D	FE502
D	CHW504
D	GLU123
D	GLU162
D	GLU266

---

site_id	BC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CHW D 504

Chain	Residue
D	CYS95
D	ARG96
D	ARG118
D	CYS119
D	LEU122
D	GLU123
D	VAL125
D	LEU212
D	GLU215
D	ALA216
D	THR219
D	TYR220
D	OH503

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23487766","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W54","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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