3VU8

Metionyl-tRNA synthetase from Thermus thermophilus complexed with methionyl-adenylate analogue

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004825	molecular_function	methionine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006431	biological_process	methionyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS127
A	CYS130
A	CYS144
A	HIS147

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MDS A 602

Chain	Residue
A	TYR234
A	ILE261
A	PRO264
A	PRO10
A	ILE11
A	VAL226
A	TRP227
A	ASN233

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Motif: {"description":"'HIGH' region","evidences":[{"source":"HAMAP-Rule","id":"MF_01228","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"'KMSKS' region","evidences":[{"source":"HAMAP-Rule","id":"MF_01228","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01228","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	8
Details	M-CSA 384

Chain	Residue	Details
A	HIS19	activator, electrostatic stabiliser
A	HIS22	activator, electrostatic stabiliser
A	CYS127	metal ligand
A	CYS130	metal ligand
A	CYS144	metal ligand
A	HIS147	metal ligand
A	LYS297	activator, electrostatic stabiliser
A	LYS300	activator, electrostatic stabiliser

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