Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3VU3

Crystal structure of the Hfq and catalase HPII complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004096	molecular_function	catalase activity
A	0004601	molecular_function	peroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006972	biological_process	hyperosmotic response
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
C	0000049	molecular_function	tRNA binding
C	0003677	molecular_function	DNA binding
C	0003681	molecular_function	bent DNA binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008033	biological_process	tRNA processing
C	0034337	biological_process	RNA folding
C	0040033	biological_process	sRNA-mediated post-transcriptional gene silencing
C	0043487	biological_process	regulation of RNA stability
C	0043590	cellular_component	bacterial nucleoid
C	0045974	biological_process	regulation of translation, ncRNA-mediated
C	0045975	biological_process	positive regulation of translation, ncRNA-mediated
C	0140691	molecular_function	RNA folding chaperone
D	0000049	molecular_function	tRNA binding
D	0003677	molecular_function	DNA binding
D	0003681	molecular_function	bent DNA binding
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008033	biological_process	tRNA processing
D	0034337	biological_process	RNA folding
D	0040033	biological_process	sRNA-mediated post-transcriptional gene silencing
D	0043487	biological_process	regulation of RNA stability
D	0043590	cellular_component	bacterial nucleoid
D	0045974	biological_process	regulation of translation, ncRNA-mediated
D	0045975	biological_process	positive regulation of translation, ncRNA-mediated
D	0140691	molecular_function	RNA folding chaperone
E	0000049	molecular_function	tRNA binding
E	0003677	molecular_function	DNA binding
E	0003681	molecular_function	bent DNA binding
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008033	biological_process	tRNA processing
E	0034337	biological_process	RNA folding
E	0040033	biological_process	sRNA-mediated post-transcriptional gene silencing
E	0043487	biological_process	regulation of RNA stability
E	0043590	cellular_component	bacterial nucleoid
E	0045974	biological_process	regulation of translation, ncRNA-mediated
E	0045975	biological_process	positive regulation of translation, ncRNA-mediated
E	0140691	molecular_function	RNA folding chaperone
F	0000049	molecular_function	tRNA binding
F	0003677	molecular_function	DNA binding
F	0003681	molecular_function	bent DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008033	biological_process	tRNA processing
F	0034337	biological_process	RNA folding
F	0040033	biological_process	sRNA-mediated post-transcriptional gene silencing
F	0043487	biological_process	regulation of RNA stability
F	0043590	cellular_component	bacterial nucleoid
F	0045974	biological_process	regulation of translation, ncRNA-mediated
F	0045975	biological_process	positive regulation of translation, ncRNA-mediated
F	0140691	molecular_function	RNA folding chaperone
G	0000049	molecular_function	tRNA binding
G	0003677	molecular_function	DNA binding
G	0003681	molecular_function	bent DNA binding
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008033	biological_process	tRNA processing
G	0034337	biological_process	RNA folding
G	0040033	biological_process	sRNA-mediated post-transcriptional gene silencing
G	0043487	biological_process	regulation of RNA stability
G	0043590	cellular_component	bacterial nucleoid
G	0045974	biological_process	regulation of translation, ncRNA-mediated
G	0045975	biological_process	positive regulation of translation, ncRNA-mediated
G	0140691	molecular_function	RNA folding chaperone
H	0000049	molecular_function	tRNA binding
H	0003677	molecular_function	DNA binding
H	0003681	molecular_function	bent DNA binding
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008033	biological_process	tRNA processing
H	0034337	biological_process	RNA folding
H	0040033	biological_process	sRNA-mediated post-transcriptional gene silencing
H	0043487	biological_process	regulation of RNA stability
H	0043590	cellular_component	bacterial nucleoid
H	0045974	biological_process	regulation of translation, ncRNA-mediated
H	0045975	biological_process	positive regulation of translation, ncRNA-mediated
H	0140691	molecular_function	RNA folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM A 801

Chain	Residue
A	ARG125
A	HIS275
A	PHE391
A	LEU407
A	ARG411
A	SER414
A	TYR415
A	THR418
A	GLN419
A	HIS128
A	ARG165
A	GLY184
A	VAL199
A	GLY200
A	ASN201
A	PHE206
A	PHE214

Functional Information from PROSITE/UniProt

site_id	PS00437
Number of Residues	9
Details	CATALASE_1 Catalase proximal heme-ligand signature. RLFSYtDTQ

Chain	Residue	Details
A	ARG411-GLN419

site_id	PS00438
Number of Residues	17
Details	CATALASE_2 Catalase proximal active site signature. FdHeripERivHarGSA

Chain	Residue	Details
A	PHE117-ALA133

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10013","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"3'-histidyl-3-tyrosine (His-Tyr)"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	177
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 573

Chain	Residue	Details
A	HIS128	proton shuttle (general acid/base)
A	ASN201	electrostatic stabiliser
A	HIS392	proton shuttle (general acid/base)

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)