3VTK
THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE 1 IN COMPLEX WITH ADP AND 5-IODO-DEOXYURIDINE-MONOPHOSPHATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004797 | molecular_function | thymidine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006230 | biological_process | TMP biosynthetic process |
| A | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 5IU A 500 |
| Chain | Residue |
| A | HIS58 |
| A | TYR172 |
| A | GLU225 |
| A | HOH602 |
| A | HOH605 |
| A | LYS62 |
| A | GLU83 |
| A | ILE97 |
| A | TYR101 |
| A | GLN125 |
| A | MET128 |
| A | ARG163 |
| A | ALA168 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ADP A 400 |
| Chain | Residue |
| A | GLY59 |
| A | MET60 |
| A | GLY61 |
| A | LYS62 |
| A | THR63 |
| A | THR64 |
| A | ARG216 |
| A | ARG220 |
| A | GLN331 |
| A | HOH605 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_04029 |
| Chain | Residue | Details |
| A | GLU83 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04029 |
| Chain | Residue | Details |
| A | GLY56 | |
| A | TYR101 | |
| A | GLN125 | |
| A | ARG216 | |
| A | ARG222 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| A | GLU83 | |
| A | ARG222 | |
| A | GLY59 | |
| A | ARG163 |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 588 |
| Chain | Residue | Details |
| A | LYS62 | electrostatic stabiliser, polar interaction |
| A | GLU83 | proton acceptor, proton donor |
| A | ASP162 | metal ligand |
| A | ARG163 | electrostatic stabiliser, polar interaction |
| A | ARG220 | electrostatic stabiliser, polar interaction |
| A | ARG222 | electrostatic stabiliser, polar interaction |
| A | GLU225 | electrostatic stabiliser, polar interaction |
