3VOS

Crystal structure of Aspartate semialdehyde dehydrogenase Complexed With glycerol and sulfate From Mycobacterium tuberculosis H37Rv

Replaces:  3LLGReplaces:  3KUB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006520	biological_process	amino acid metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009067	biological_process	aspartate family amino acid biosynthetic process
A	0009085	biological_process	lysine biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0009097	biological_process	isoleucine biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0046983	molecular_function	protein dimerization activity
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0071266	biological_process	'de novo' L-methionine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
A	CYS130
A	GLN157
A	GLY161
A	GLU224
A	ARG249
A	HIS256
A	SO4404
A	HOH825
A	HOH850

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 402

Chain	Residue
A	GLY188
A	GLY189
A	LEU191
A	PHE193
A	HOH613
A	HOH621
A	HOH680
A	HOH685
A	HOH722
A	HOH835

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	ARG229
A	PHE230
A	ARG233
A	HOH682
A	HOH849

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 404

Chain	Residue
A	ARG99
A	ASN129
A	CYS130
A	LYS227
A	GOL401
A	HOH786
A	HOH851
A	HOH909

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 405

Chain	Residue
A	GLU271
A	ARG274
A	HOH842

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 406

Chain	Residue
A	HIS118
A	ARG120
A	HOH933

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 407

Chain	Residue
A	ARG233
A	HOH662
A	HOH930

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 408

Chain	Residue
A	ARG43
A	GLU53
A	GLY73
A	SER74
A	HOH862
A	HOH869
A	HOH871
A	HOH898

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 409

Chain	Residue
A	GLY12
A	GLN13
A	VAL14
A	ARG43
A	GLY163
A	LEU164
A	HOH629
A	HOH823
A	HOH876
A	HOH910

---

Functional Information from PROSITE/UniProt

site_id	PS01103
Number of Residues	15
Details	ASD Aspartate-semialdehyde dehydrogenase signature. VSgtCvRVpvftGHS

Chain	Residue	Details
A	VAL243-SER257

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"22683789","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---