3VND
Crystal structure of tryptophan synthase alpha-subunit from the psychrophile Shewanella frigidimarina K14-2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006568 | biological_process | L-tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0004834 | molecular_function | tryptophan synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006568 | biological_process | L-tryptophan metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0004834 | molecular_function | tryptophan synthase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006568 | biological_process | L-tryptophan metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| E | 0000162 | biological_process | L-tryptophan biosynthetic process |
| E | 0004834 | molecular_function | tryptophan synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006568 | biological_process | L-tryptophan metabolic process |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0000162 | biological_process | L-tryptophan biosynthetic process |
| F | 0004834 | molecular_function | tryptophan synthase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006568 | biological_process | L-tryptophan metabolic process |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| G | 0000162 | biological_process | L-tryptophan biosynthetic process |
| G | 0004834 | molecular_function | tryptophan synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0006568 | biological_process | L-tryptophan metabolic process |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| H | 0000162 | biological_process | L-tryptophan biosynthetic process |
| H | 0004834 | molecular_function | tryptophan synthase activity |
| H | 0005829 | cellular_component | cytosol |
| H | 0006568 | biological_process | L-tryptophan metabolic process |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | GLY212 |
| A | PHE213 |
| A | GLY214 |
| A | GLY235 |
| A | SER236 |
| A | HOH443 |
| A | HOH464 |
| A | HOH478 |
| B | PRO63 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | THR78 |
| A | SER79 |
| A | SER80 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 303 |
| Chain | Residue |
| A | HIS93 |
| A | PRO94 |
| A | ASP95 |
| A | MET96 |
| A | HOH537 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | HIS93 |
| B | PRO94 |
| B | ASP95 |
| B | MET96 |
| B | HOH419 |
| B | HOH487 |
| B | HOH548 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| A | PRO63 |
| B | GLY212 |
| B | PHE213 |
| B | GLY214 |
| B | GLY235 |
| B | SER236 |
| B | HOH433 |
| B | HOH517 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PE8 B 303 |
| Chain | Residue |
| A | ALA60 |
| A | ASP61 |
| A | ALA130 |
| A | HOH464 |
| A | HOH488 |
| B | ASP61 |
| B | ALA130 |
| B | ILE154 |
| B | HOH518 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 301 |
| Chain | Residue |
| C | GLY212 |
| C | PHE213 |
| C | GLY214 |
| C | GLY235 |
| C | SER236 |
| C | HOH423 |
| C | HOH489 |
| C | HOH537 |
| D | PRO63 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 302 |
| Chain | Residue |
| C | HIS93 |
| C | PRO94 |
| C | ASP95 |
| C | MET96 |
| C | HOH402 |
| C | HOH455 |
| C | HOH463 |
| C | HOH551 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 301 |
| Chain | Residue |
| D | THR78 |
| D | SER79 |
| D | SER80 |
| D | ASN110 |
| D | HOH428 |
| D | HOH462 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 302 |
| Chain | Residue |
| D | HIS93 |
| D | PRO94 |
| D | ASP95 |
| D | MET96 |
| D | HOH416 |
| D | HOH420 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| C | PRO63 |
| D | GLY212 |
| D | PHE213 |
| D | GLY214 |
| D | GLY235 |
| D | SER236 |
| D | HOH408 |
| D | HOH412 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PE8 D 304 |
| Chain | Residue |
| C | ALA60 |
| C | ILE154 |
| C | PHE213 |
| D | ALA60 |
| D | ASP61 |
| D | ALA130 |
| D | ILE154 |
| D | PRO157 |
| D | LEU178 |
| D | PHE213 |
| D | HOH435 |
| D | HOH472 |
| D | HOH481 |
| D | HOH482 |
| D | HOH485 |
| D | HOH522 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 E 301 |
| Chain | Residue |
| E | HOH403 |
| E | HOH424 |
| F | PRO63 |
| E | GLY212 |
| E | PHE213 |
| E | GLY214 |
| E | GLY235 |
| E | SER236 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 302 |
| Chain | Residue |
| E | HIS93 |
| E | ASP95 |
| E | MET96 |
| E | HOH461 |
| E | HOH489 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PE8 E 303 |
| Chain | Residue |
| E | ALA60 |
| E | ASP61 |
| E | ALA130 |
| E | ILE154 |
| E | PRO157 |
| E | HOH507 |
| E | HOH541 |
| F | ASP61 |
| F | ILE154 |
| F | PHE213 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F 301 |
| Chain | Residue |
| E | PRO63 |
| F | GLY212 |
| F | PHE213 |
| F | GLY214 |
| F | GLY235 |
| F | SER236 |
| F | HOH417 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F 302 |
| Chain | Residue |
| F | HIS93 |
| F | PRO94 |
| F | ASP95 |
| F | MET96 |
| F | HOH414 |
| F | HOH471 |
| F | HOH476 |
| site_id | BC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 G 301 |
| Chain | Residue |
| G | HIS93 |
| G | PRO94 |
| G | ASP95 |
| G | MET96 |
| G | HOH438 |
| G | HOH462 |
| G | HOH469 |
| G | HOH478 |
| G | HOH514 |
| site_id | CC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 G 302 |
| Chain | Residue |
| G | GLY212 |
| G | PHE213 |
| G | GLY214 |
| G | GLY235 |
| G | SER236 |
| G | HOH402 |
| G | HOH441 |
| G | HOH472 |
| G | HOH477 |
| H | PRO63 |
| site_id | CC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PE8 G 303 |
| Chain | Residue |
| G | ASP61 |
| G | ALA130 |
| G | PRO157 |
| G | PHE213 |
| G | HOH419 |
| G | HOH490 |
| G | HOH495 |
| G | HOH502 |
| H | ALA130 |
| H | HOH474 |
| site_id | CC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 H 301 |
| Chain | Residue |
| G | PRO63 |
| H | GLY212 |
| H | PHE213 |
| H | GLY214 |
| H | GLY235 |
| H | SER236 |
| H | HOH419 |
| H | HOH432 |
| H | HOH463 |
| H | HOH468 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 H 302 |
| Chain | Residue |
| H | GLN92 |
| H | HIS93 |
| H | PRO94 |
| H | ASP95 |
| H | MET96 |
| H | HOH444 |
| H | HOH472 |
| H | HOH513 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGfPFSDPLADG |
| Chain | Residue | Details |
| A | LEU49-GLY62 |
