3VKX

Structure of PCNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005652	cellular_component	nuclear lamina
A	0005654	cellular_component	nucleoplasm
A	0005657	cellular_component	replication fork
A	0005813	cellular_component	centrosome
A	0006260	biological_process	DNA replication
A	0006272	biological_process	leading strand elongation
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006298	biological_process	mismatch repair
A	0006325	biological_process	chromatin organization
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007507	biological_process	heart development
A	0019899	molecular_function	enzyme binding
A	0019985	biological_process	translesion synthesis
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0030855	biological_process	epithelial cell differentiation
A	0030894	cellular_component	replisome
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031297	biological_process	replication fork processing
A	0032139	molecular_function	dinucleotide insertion or deletion binding
A	0032355	biological_process	response to estradiol
A	0032405	molecular_function	MutLalpha complex binding
A	0033993	biological_process	response to lipid
A	0034644	biological_process	cellular response to UV
A	0035035	molecular_function	histone acetyltransferase binding
A	0042802	molecular_function	identical protein binding
A	0043596	cellular_component	nuclear replication fork
A	0043626	cellular_component	PCNA complex
A	0044849	biological_process	estrous cycle
A	0044877	molecular_function	protein-containing complex binding
A	0045739	biological_process	positive regulation of DNA repair
A	0045740	biological_process	positive regulation of DNA replication
A	0046686	biological_process	response to cadmium ion
A	0070062	cellular_component	extracellular exosome
A	0070182	molecular_function	DNA polymerase binding
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070557	cellular_component	PCNA-p21 complex
A	0071548	biological_process	response to dexamethasone
A	0097421	biological_process	liver regeneration
A	0140861	biological_process	DNA repair-dependent chromatin remodeling
A	1902065	biological_process	response to L-glutamate
A	1902969	biological_process	mitotic DNA replication
A	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE T3 A 301

Chain	Residue
A	MET40
A	HOH379
A	LEU47
A	GLY127
A	PRO129
A	GLN131
A	ASP232
A	PRO234
A	TYR250
A	ILE255

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 262

Chain	Residue
A	GLY142
A	GLU143
A	ARG146
A	HOH359
A	HOH364
A	HOH378

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 263

Chain	Residue
A	LYS168
A	LYS181
A	HOH356

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 264

Chain	Residue
A	ARG53
A	GLU238
A	LYS240
A	GLY245
A	HIS246
A	HOH357

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 265

Chain	Residue
A	ARG146
A	ARG149

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 266

Chain	Residue
A	TYR133
A	SER228
A	VAL236
A	GLU238
A	LYS248
A	TYR250
A	HOH323

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 267

Chain	Residue
A	GLN49
A	THR51
A	HIS246
A	HOH357
A	HOH376

---

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL

Chain	Residue	Details
A	ARG61-LEU79

---

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF

Chain	Residue	Details
A	GLY34-PHE57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	93
Details	Region: {"description":"Interaction with NUDT15","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"17115032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38459011","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17108083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17130289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---