3VGB

Crystal structure of glycosyltrehalose trehalohydrolase (GTHase) from Sulfolobus solfataricus KM1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0005992	biological_process	trehalose biosynthetic process
A	0033942	molecular_function	4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC A 1001

Chain	Residue
A	GLN323
A	ARG382
A	GLY383
A	LYS384
A	ASN448
A	HOH2085
A	HOH2104
A	HOH2119

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1101

Chain	Residue
A	ARG123
A	LYS124
A	TRP467
A	SER537
A	GLU548
A	HOH2032
A	PRO114

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1102

Chain	Residue
A	GLU115
A	GLY116
A	SER163
A	PHE460
A	HOH2050
A	HOH2092

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1103

Chain	Residue
A	TYR152
A	HIS192
A	TRP215
A	ASP252
A	GLU283
A	ASP377
A	HOH2147

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"22334583","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"22334583","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22334583","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"22334583","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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