3VE7
Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE BMP A 301 |
| Chain | Residue |
| A | SER7 |
| A | GLY180 |
| A | ARG181 |
| A | HOH402 |
| A | HOH405 |
| A | HOH413 |
| A | HOH416 |
| A | HOH417 |
| A | HOH421 |
| B | ASP61 |
| B | ILE62 |
| A | ASP9 |
| B | THR65 |
| A | LYS28 |
| A | ASP56 |
| A | LYS58 |
| A | MET107 |
| A | SER108 |
| A | PRO157 |
| A | GLN162 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | ARG138 |
| A | PRO139 |
| A | SER140 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE BMP B 301 |
| Chain | Residue |
| A | ASP61 |
| A | ILE62 |
| A | THR65 |
| B | SER7 |
| B | ASP9 |
| B | LYS28 |
| B | ASP56 |
| B | LYS58 |
| B | MET107 |
| B | SER108 |
| B | PRO157 |
| B | GLN162 |
| B | GLY180 |
| B | ARG181 |
| B | HOH403 |
| B | HOH406 |
| B | HOH409 |
| B | HOH410 |
| B | HOH415 |
| B | HOH419 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY B 302 |
| Chain | Residue |
| B | PRO110 |
| B | ARG138 |
| B | HOH471 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY B 303 |
| Chain | Residue |
| A | HOH434 |
| A | HOH513 |
| B | GLY38 |
| B | LYS39 |
| B | GLU40 |
| B | HOH570 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY B 304 |
| Chain | Residue |
| B | LEU35 |
| B | HOH446 |
| B | HOH456 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 305 |
| Chain | Residue |
| B | SER186 |
| B | ARG191 |
| B | LYS192 |
| B | HOH575 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 306 |
| Chain | Residue |
| B | ARG138 |
| B | PRO139 |
| B | SER140 |
