3VD6

Both Zn Fingers of GATA1 Bound to Palindromic DNA Recognition Site, P21 Crystal Form

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0008270	molecular_function	zinc ion binding
C	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 101

Chain	Residue
A	DT9
A	DC10
C	ARG202

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 500

Chain	Residue
C	CYS204
C	CYS207
C	CYS225
C	CYS228

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 501

Chain	Residue
C	CYS279
C	CYS282
C	CYS258
C	CYS261

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 502

Chain	Residue
C	ASP218
C	HIS222

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Functional Information from PROSITE/UniProt

site_id	PS00344
Number of Residues	25
Details	GATA_ZN_FINGER_1 GATA-type zinc finger domain. CvNCgata..TplWRRdrt.Ghyl...CNAC

Chain	Residue	Details
C	CYS204-CYS228
C	CYS258-CYS282

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ZN_FING: GATA-type 1 => ECO:0000255|PROSITE-ProRule:PRU00094

Chain	Residue	Details
C	CYS204-CYS228

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site_id	SWS_FT_FI2
Number of Residues	24
Details	ZN_FING: GATA-type 2 => ECO:0000255|PROSITE-ProRule:PRU00094

Chain	Residue	Details
C	CYS258-CYS282

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by EP300 => ECO:0000250|UniProtKB:P15976

Chain	Residue	Details
C	LYS233
C	LYS245

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by EP300 => ECO:0000250

Chain	Residue	Details
C	LYS246

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by CREBBP => ECO:0000269|PubMed:10207073

Chain	Residue	Details
C	LYS252

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site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21536911

Chain	Residue	Details
C	LYS308
C	LYS314
C	LYS315

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:8206977

Chain	Residue	Details
C	SER310

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by CREBBP => ECO:0000269|PubMed:10207073, ECO:0000269|PubMed:21536911

Chain	Residue	Details
C	LYS312

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