Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 200 |
| Chain | Residue |
| A | ARG51 |
| A | SER73 |
| A | SER74 |
| A | THR75 |
| A | ARG115 |
| A | HOH336 |
| A | HOH338 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 201 |
| Chain | Residue |
| A | VAL52 |
| A | THR53 |
| A | GLY113 |
| A | HOH332 |
| A | HOH346 |
| A | GLY50 |
| A | ARG51 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 202 |
| Chain | Residue |
| A | HIS78 |
| A | PRO87 |
| A | SER88 |
| A | ASN90 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGkgggLPWkikk.DmefFktvT |
| Chain | Residue | Details |
| A | GLY14-THR36 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ALA8 | |
| A | GLY14 | |
| A | ASP28 | |
| A | ARG51 | |
| A | ARG67 | |
| A | SER73 | |
| A | GLY112 | |
