3V8H
Crystal structure of Thymidylate Synthase from Burkholderia thailandensis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| C | 0004799 | molecular_function | thymidylate synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006231 | biological_process | dTMP biosynthetic process |
| C | 0006235 | biological_process | dTTP biosynthetic process |
| C | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| D | 0004799 | molecular_function | thymidylate synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006231 | biological_process | dTMP biosynthetic process |
| D | 0006235 | biological_process | dTTP biosynthetic process |
| D | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CIT A 400 |
| Chain | Residue |
| A | LEU189 |
| A | CYS192 |
| A | ARG214 |
| A | SER215 |
| A | HIS255 |
| A | TYR257 |
| D | ARG172 |
| D | ARG173 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 324 |
| Chain | Residue |
| A | ARG67 |
| A | ASP104 |
| A | VAL108 |
| A | HOH1030 |
| A | ALA65 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 325 |
| Chain | Residue |
| A | ALA74 |
| A | LEU75 |
| A | GLU302 |
| A | PRO303 |
| A | HOH430 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 326 |
| Chain | Residue |
| A | GLU143 |
| D | TYR116 |
| D | HIS152 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CIT B 400 |
| Chain | Residue |
| B | ARG214 |
| B | SER215 |
| B | HIS255 |
| B | TYR257 |
| C | ARG172 |
| C | ARG173 |
| C | HOH1136 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 324 |
| Chain | Residue |
| B | ALA123 |
| B | ASP124 |
| B | ALA125 |
| B | GLN126 |
| B | HOH349 |
| B | HOH674 |
| C | PRO94 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CIT C 400 |
| Chain | Residue |
| B | ARG172 |
| B | ARG173 |
| C | LEU189 |
| C | CYS192 |
| C | ARG214 |
| C | SER215 |
| C | HIS255 |
| C | TYR257 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 324 |
| Chain | Residue |
| C | ARG204 |
| C | ARG245 |
| C | HOH1084 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 324 |
| Chain | Residue |
| A | TRP179 |
| D | GLN157 |
| D | ASP160 |
| D | CYS161 |
| D | ARG173 |
| D | LEU175 |
| D | HOH385 |
