3V8H

Crystal structure of Thymidylate Synthase from Burkholderia thailandensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004799	molecular_function	thymidylate synthase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006231	biological_process	dTMP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0008168	molecular_function	methyltransferase activity
A	0009165	biological_process	nucleotide biosynthetic process
A	0016741	molecular_function	transferase activity, transferring one-carbon groups
A	0032259	biological_process	methylation
B	0004799	molecular_function	thymidylate synthase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006231	biological_process	dTMP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0008168	molecular_function	methyltransferase activity
B	0009165	biological_process	nucleotide biosynthetic process
B	0016741	molecular_function	transferase activity, transferring one-carbon groups
B	0032259	biological_process	methylation
C	0004799	molecular_function	thymidylate synthase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006231	biological_process	dTMP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0008168	molecular_function	methyltransferase activity
C	0009165	biological_process	nucleotide biosynthetic process
C	0016741	molecular_function	transferase activity, transferring one-carbon groups
C	0032259	biological_process	methylation
D	0004799	molecular_function	thymidylate synthase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006231	biological_process	dTMP biosynthetic process
D	0006235	biological_process	dTTP biosynthetic process
D	0008168	molecular_function	methyltransferase activity
D	0009165	biological_process	nucleotide biosynthetic process
D	0016741	molecular_function	transferase activity, transferring one-carbon groups
D	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT A 400

Chain	Residue
A	LEU189
A	CYS192
A	ARG214
A	SER215
A	HIS255
A	TYR257
D	ARG172
D	ARG173

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 324

Chain	Residue
A	ARG67
A	ASP104
A	VAL108
A	HOH1030
A	ALA65

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 325

Chain	Residue
A	ALA74
A	LEU75
A	GLU302
A	PRO303
A	HOH430

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 326

Chain	Residue
A	GLU143
D	TYR116
D	HIS152

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT B 400

Chain	Residue
B	ARG214
B	SER215
B	HIS255
B	TYR257
C	ARG172
C	ARG173
C	HOH1136

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 324

Chain	Residue
B	ALA123
B	ASP124
B	ALA125
B	GLN126
B	HOH349
B	HOH674
C	PRO94

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT C 400

Chain	Residue
B	ARG172
B	ARG173
C	LEU189
C	CYS192
C	ARG214
C	SER215
C	HIS255
C	TYR257

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 324

Chain	Residue
C	ARG204
C	ARG245
C	HOH1084

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 324

Chain	Residue
A	TRP179
D	GLN157
D	ASP160
D	CYS161
D	ARG173
D	LEU175
D	HOH385

---