3V7X
Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002009 | biological_process | morphogenesis of an epithelium |
A | 0004064 | molecular_function | arylesterase activity |
A | 0004089 | molecular_function | carbonate dehydratase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0015670 | biological_process | carbon dioxide transport |
A | 0016829 | molecular_function | lyase activity |
A | 0018820 | molecular_function | cyanamide hydratase activity |
A | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
A | 0032849 | biological_process | positive regulation of cellular pH reduction |
A | 0038166 | biological_process | angiotensin-activated signaling pathway |
A | 0043209 | cellular_component | myelin sheath |
A | 0044070 | biological_process | regulation of monoatomic anion transport |
A | 0045177 | cellular_component | apical part of cell |
A | 0046872 | molecular_function | metal ion binding |
A | 0046903 | biological_process | secretion |
A | 0051453 | biological_process | regulation of intracellular pH |
A | 0070050 | biological_process | neuron cellular homeostasis |
A | 0070062 | cellular_component | extracellular exosome |
A | 2001150 | biological_process | positive regulation of dipeptide transmembrane transport |
A | 2001225 | biological_process | regulation of chloride transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 2001 |
Chain | Residue |
A | HIS1094 |
A | HIS1096 |
A | HIS1119 |
A | D7A2002 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE D7A A 2002 |
Chain | Residue |
A | THR1199 |
A | THR1200 |
A | TRP1209 |
A | ZN2001 |
A | GOL2004 |
A | HOH6061 |
A | HOH6132 |
A | HOH6203 |
A | HOH6249 |
A | HOH6292 |
A | HIS1094 |
A | HIS1096 |
A | HIS1119 |
A | PHE1131 |
A | LEU1198 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 2003 |
Chain | Residue |
A | TYR1128 |
A | HOH6131 |
A | HOH6193 |
A | HOH6259 |
A | HOH6304 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE GOL A 2004 |
Chain | Residue |
A | ASN1062 |
A | HIS1064 |
A | ALA1065 |
A | ASN1067 |
A | GLN1092 |
A | HIS1094 |
A | HIS1096 |
A | THR1200 |
A | D7A2002 |
A | HOH6018 |
A | HOH6132 |
A | HOH6212 |
A | HOH6214 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 2005 |
Chain | Residue |
A | TYR1007 |
A | PRO1013 |
A | ASP1243 |
A | TRP1245 |
A | HOH6164 |
A | HOH6229 |
A | HOH6288 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL A 2006 |
Chain | Residue |
A | HIS1017 |
A | LYS1018 |
A | PRO1021 |
A | PRO1046 |
A | LEU1047 |
A | SER1048 |
A | HOH6032 |
A | HOH6056 |
A | HOH6300 |
A | HOH6318 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 2007 |
Chain | Residue |
A | TYR1114 |
A | LYS1149 |
A | PRO1215 |
A | HOH6044 |
A | HOH6209 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE MBO A 2008 |
Chain | Residue |
A | VAL1135 |
A | GLN1136 |
A | GLN1137 |
A | PRO1138 |
A | GLU1205 |
A | CYS1206 |
A | HOH6157 |
A | HOH6189 |
A | HOH6261 |
A | HOH6268 |
site_id | AC9 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MBO A 2009 |
Chain | Residue |
A | GLY1006 |
A | TYR1007 |
A | GLY1008 |
A | ASN1011 |
A | PHE1231 |
A | GLU1239 |
A | HOH6042 |
A | HOH6168 |
A | HOH6256 |
A | HOH6287 |
A | HOH6293 |
A | HOH6333 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MBO A 2010 |
Chain | Residue |
A | HIS1004 |
A | ASN1062 |
A | GLY1063 |
A | HIS1064 |
A | HOH6161 |
A | HOH6224 |
A | HOH6238 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MBO A 2011 |
Chain | Residue |
A | HIS1003 |
A | HOH6108 |
A | HOH6283 |
Functional Information from PROSITE/UniProt
site_id | PS00162 |
Number of Residues | 17 |
Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdkkkYaaELHLV |
Chain | Residue | Details |
A | SER1105-VAL1121 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:15667203, ECO:0000305|PubMed:17330962 |
Chain | Residue | Details |
A | HIS1064 |
Chain | Residue | Details |
A | HIS1094 |
Chain | Residue | Details |
A | HIS1096 | |
A | HIS1119 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:19520834 |
Chain | Residue | Details |
A | THR1199 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Fine-tunes the proton-transfer properties of H-64 => ECO:0000305|PubMed:17330962 |
Chain | Residue | Details |
A | TYR1007 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Fine-tunes the proton-transfer properties of H-64; involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962 |
Chain | Residue | Details |
A | ASN1062 | |
A | ASN1067 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962 |
Chain | Residue | Details |
A | GLN1092 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P27139 |
Chain | Residue | Details |
A | SER1002 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER1166 | |
A | SER1173 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 216 |
Chain | Residue | Details |
A | HIS1064 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | HIS1094 | metal ligand |
A | HIS1096 | metal ligand |
A | GLU1106 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | HIS1119 | metal ligand |
A | THR1199 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity |