3V5U

Structure of Sodium/Calcium Exchanger from Methanocaldococcus jannaschii DSM 2661

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005262	molecular_function	calcium channel activity
A	0005886	cellular_component	plasma membrane
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0008273	molecular_function	calcium, potassium:sodium antiporter activity
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 701

Chain	Residue
A	ALA47
A	THR50
A	SER51
A	GLU213
A	SER236

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 702

Chain	Residue
A	NA704
A	THR50
A	GLU54
A	THR209
A	GLU213

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 703

Chain	Residue
A	GLU54
A	SER77
A	ALA206
A	THR209
A	SER210

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 704

Chain	Residue
A	SER51
A	GLU54
A	ASN81
A	GLU213
A	ASP240
A	CA702

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 705

Chain	Residue
A	ILE118
A	ASP121
A	GLY122
A	ASP127
A	OLC710
A	HOH849

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 706

Chain	Residue
A	ILE14
A	HOH897

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT A 707

Chain	Residue
A	TYR60

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 708

Chain	Residue
A	LEU193
A	HOH896

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 709

Chain	Residue
A	ASN35
A	LYS279
A	HOH804
A	HOH821

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE OLC A 710

Chain	Residue
A	VAL117
A	ILE118
A	ASP121
A	ASP127
A	ALA186
A	CA705
A	OLC711
A	OLC712

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLC A 711

Chain	Residue
A	PHE114
A	ASP127
A	LEU134
A	TYR138
A	OLC710
A	OLC724
A	HOH853

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OLC A 712

Chain	Residue
A	PHE182
A	ALA190
A	ASP197
A	LYS198
A	GLY201
A	OLC710

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MYS A 713

Chain	Residue
A	ALA116
A	ASN258

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MYS A 714

Chain	Residue
A	VAL143

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MYS A 715

Chain	Residue
A	TRP283
A	ILE286

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE A 716

Chain	Residue
A	TYR17
A	SER20
A	MET215
A	ALA219
A	LYS222
A	OLC724

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MYS A 718

Chain	Residue
A	ILE136
A	ARG140
A	ALA297
A	MYS722
A	HOH875

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MYS A 719

Chain	Residue
A	ILE91
A	LEU250
A	ILE293

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MYS A 720

Chain	Residue
A	VAL259
A	SER298
A	LEU299
A	ARG300
A	HOH806

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MYS A 722

Chain	Residue
A	ALA297
A	SER298
A	MYS718

---

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLC A 723

Chain	Residue
A	LEU52
A	PRO53
A	LEU56
A	LEU172
A	LEU176
A	ALA179
A	GLU180

---

site_id	CC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE OLC A 724

Chain	Residue
A	ALA206
A	PHE207
A	TYR292
A	OLC711
A	1PE716
A	HOH812
A	HOH871
A	TYR17
A	CYS80
A	LEU88
A	VAL130
A	ILE133
A	ILE137
A	THR203
A	LEU204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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