3V3M

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease in Complex with N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 0EN A 401

Chain	Residue
A	THR26
A	HIS164
A	MET165
A	GLU166
A	HOH820
A	HIS41
A	PHE140
A	LEU141
A	ASN142
A	GLY143
A	SER144
A	CYS145
A	HIS163

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 402

Chain	Residue
A	CYS22
A	GLY23
A	THR24
A	THR25
A	VAL42
A	CYS44
A	ALA46

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 403

Chain	Residue
A	ASN84
A	HOH517

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:16306590

Chain	Residue	Details
A	HIS41

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772

Chain	Residue	Details
A	CYS145

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000269|PubMed:14561748

Chain	Residue	Details
A	GLN306

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