3V3B

Structure of the Stapled p53 Peptide Bound to Mdm2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 2

Chain	Residue
A	PRO32
A	LEU33
B	PRO32
B	LEU33

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 3

Chain	Residue
A	GLU25
A	THR26
A	MET50
A	LYS51

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 4

Chain	Residue
A	VAL109

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 5

Chain	Residue
A	GLU95
A	ARG97
A	LYS98

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 6

Chain	Residue
A	LYS64
A	ASP80
A	LEU81

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 1

Chain	Residue
B	SER92

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site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 7

Chain	Residue
B	GLU69

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site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 8

Chain	Residue
B	LYS64
B	ASP80
B	LEU81

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site_id	AC9
Number of Residues	12
Details	BINDING SITE FOR CHAIN C OF SAH-P53-8 STAPLED-PEPTIDE

Chain	Residue
A	GLU25
A	THR49
B	LEU54
B	PHE55
B	LEU57
B	GLY58
B	GLN59
B	ILE61
B	GLN72
B	HIS73
B	VAL93
B	HIS96

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site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR CHAIN D OF SAH-P53-8 STAPLED-PEPTIDE

Chain	Residue
A	LEU54
A	GLY58
A	ILE61
A	TYR67
A	GLN72
A	HIS73
A	VAL93
A	TYR100
D	HOH110

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