Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

3V1U

Crystal structure of a beta-ketoacyl reductase FabG4 from Mycobacterium tuberculosis H37Rv complexed with NAD+ and Hexanoyl-CoA at 2.5 Angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0005576cellular_componentextracellular region
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0009274cellular_componentpeptidoglycan-based cell wall
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0035336biological_processlong-chain fatty-acyl-CoA metabolic process
A0046459biological_processshort-chain fatty acid metabolic process
A0046677biological_processresponse to antibiotic
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NAD A 501
ChainResidue
AGLY220
AASN295
AALA296
AILE298
AVAL318
ALEU345
ASER346
ASER347
ATYR360
ALYS364
APRO390
AARG223
AGLY391
AILE393
AGLN396
AHXC502
AHOH630
AHOH709
AGLY224
AILE225
AASP244
AVAL245
ALEU266
AASP267
AVAL268

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE HXC A 502
ChainResidue
AGLU151
AARG153
AGLY297
ATHR299
AASP301
ALYS302
ALEU303
AASN306
AASN354
AARG355
ANAD501
AHOH669

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZPG A 503
ChainResidue
AGLU338
AALA379
AALA380

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SiagiagnrgQtnYATTKAGMiGITqALA
ChainResidueDetails
ASER347-ALA375

239149

PDB entries from 2025-07-23

PDB statisticsPDBj update infoContact PDBjnumon