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3V0X

Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007586biological_processdigestion
A0008236molecular_functionserine-type peptidase activity
A0046872molecular_functionmetal ion binding
A0097180cellular_componentserine protease inhibitor complex
A0097655molecular_functionserpin family protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DSG A 115
ChainResidue
ALEU114
ASER116
AARG117
AVAL118
AHOH274

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 480
ChainResidue
AGLU80
AHOH395
AHOH4
AGLU70
AASN72
AVAL75

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ANH A 481
ChainResidue
AHOH2
AHOH5
ALEU137
ALYS159
AASP189
AALA190
AGLN192
ASER195
ACYS201
ASER202
AGLY203
ATRP215
AGLY216
AGLY219
ACYS220
AGLY226

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 483
ChainResidue
AGLU80
AGLN81
APHE82
AHOH327
AHOH368

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
ChainResidueDetails
AVAL53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPVV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues7
DetailsBINDING:
ChainResidueDetails
AGLU70
AASN72
AVAL75
AGLU80
AASP189
AGLN192
ASER195

227344

PDB entries from 2024-11-13

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