3UZT

Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0002026	biological_process	regulation of the force of heart contraction
A	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
A	0002031	biological_process	G protein-coupled receptor internalization
A	0003108	biological_process	negative regulation of the force of heart contraction by chemical signal
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004703	molecular_function	G protein-coupled receptor kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0006886	biological_process	intracellular protein transport
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
A	0007217	biological_process	tachykinin receptor signaling pathway
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019079	biological_process	viral genome replication
A	0031623	biological_process	receptor internalization
A	0031694	molecular_function	alpha-2A adrenergic receptor binding
A	0031755	molecular_function	Edg-2 lysophosphatidic acid receptor binding
A	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0045988	biological_process	negative regulation of striated muscle contraction
A	0046718	biological_process	symbiont entry into host cell
A	0047696	molecular_function	beta-adrenergic receptor kinase activity
A	0060048	biological_process	cardiac muscle contraction
A	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	1901081	biological_process	negative regulation of relaxation of smooth muscle
A	1903566	biological_process	positive regulation of protein localization to cilium

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 690

Chain	Residue
A	ASP335
B	U50

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK

Chain	Residue	Details
A	ILE197-LYS220

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL

Chain	Residue	Details
A	VAL313-LEU325

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	121
Details	Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---