3UUB

The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in solution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0005267	molecular_function	potassium channel activity
F	0005272	molecular_function	sodium channel activity
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0006814	biological_process	sodium ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0035725	biological_process	sodium ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0071805	biological_process	potassium ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0005267	molecular_function	potassium channel activity
G	0005272	molecular_function	sodium channel activity
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0006814	biological_process	sodium ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0035725	biological_process	sodium ion transmembrane transport
G	0042802	molecular_function	identical protein binding
G	0071805	biological_process	potassium ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0005267	molecular_function	potassium channel activity
H	0005272	molecular_function	sodium channel activity
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006813	biological_process	potassium ion transport
H	0006814	biological_process	sodium ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0035725	biological_process	sodium ion transmembrane transport
H	0042802	molecular_function	identical protein binding
H	0071805	biological_process	potassium ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0005267	molecular_function	potassium channel activity
I	0005272	molecular_function	sodium channel activity
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006813	biological_process	potassium ion transport
I	0006814	biological_process	sodium ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0035725	biological_process	sodium ion transmembrane transport
I	0042802	molecular_function	identical protein binding
I	0071805	biological_process	potassium ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0005267	molecular_function	potassium channel activity
J	0005272	molecular_function	sodium channel activity
J	0005886	cellular_component	plasma membrane
J	0006811	biological_process	monoatomic ion transport
J	0006813	biological_process	potassium ion transport
J	0006814	biological_process	sodium ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0035725	biological_process	sodium ion transmembrane transport
J	0042802	molecular_function	identical protein binding
J	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC A 318

Chain	Residue
A	PHE121
A	TYR194
A	TYR254
A	ASN307
A	PHE315

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PLC A 320

Chain	Residue
A	VAL275
A	TYR278
E	TRP217

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PLC A 321

Chain	Residue
A	TRP217

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT A 322

Chain	Residue
A	ALA237
A	THR244
B	LMT322

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 324

Chain	Residue
A	PHE78

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PLC B 318

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	ILE198
B	TYR254
B	ASN307
B	PHE315

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PLC B 320

Chain	Residue
B	TRP217
C	VAL275
C	TYR278

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT B 321

Chain	Residue
B	ALA237
B	LMT322

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT B 322

Chain	Residue
A	LMT322
B	LMT321

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 323

Chain	Residue
B	PHE78
B	ARG85

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC C 318

Chain	Residue
C	PHE121
C	TYR194
C	TYR254
C	ASN307
C	PHE315

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT C 320

Chain	Residue
C	ALA237

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 321

Chain	Residue
C	PHE78
C	ARG85

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC D 318

Chain	Residue
D	PHE121
D	TYR194
D	TYR254
D	ASN307
D	PHE315

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLC D 320

Chain	Residue
C	TRP217
D	TYR278

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT D 321

Chain	Residue
D	ALA237

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 322

Chain	Residue
D	PHE78

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC E 318

Chain	Residue
E	PHE121
E	TYR194
E	TYR254
E	ASN307
E	PHE315

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC E 320

Chain	Residue
D	TRP217
E	ILE271
E	THR274
E	TYR278

---

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT E 321

Chain	Residue
E	ALA237
E	THR244

---

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 322

Chain	Residue
E	PHE78

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC F 318

Chain	Residue
F	PHE121
F	TYR194
F	TYR254
F	ASN307
F	PLC319

---

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PLC F 319

Chain	Residue
F	PLC318

---

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PLC F 320

Chain	Residue
F	TRP217

---

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT F 321

Chain	Residue
F	ALA237
F	THR244
G	LMT321

---

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 323

Chain	Residue
F	PHE78
F	ARG85

---

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC G 318

Chain	Residue
G	PHE121
G	TYR194
G	TYR254
G	ASN307

---

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT G 320

Chain	Residue
G	ALA237
G	LMT321

---

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT G 321

Chain	Residue
F	LMT321
G	LMT320
J	LMT321

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 322

Chain	Residue
G	PHE78
G	ARG85

---

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC H 318

Chain	Residue
H	PHE121
H	TYR194
H	TYR254
H	ASN307
H	PHE315

---

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLC H 320

Chain	Residue
H	TRP217
I	TYR278

---

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PLC H 321

Chain	Residue
G	TRP217
H	VAL275
H	TYR278

---

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT H 322

Chain	Residue
H	ALA237
I	ALA237
I	ILE240

---

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT H 323

Chain	Residue
G	ALA237
H	ALA237
H	ILE240
H	THR244

---

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 324

Chain	Residue
H	ARG85
H	PHE78

---

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC I 318

Chain	Residue
I	PHE121
I	TYR194
I	TYR254
I	ASN307
I	PHE315

---

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PLC I 320

Chain	Residue
I	TRP217
J	ILE271
J	TYR278

---

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL I 321

Chain	Residue
I	PHE78
I	ARG85

---

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PLC J 318

Chain	Residue
J	PHE121
J	TYR194
J	LEU206
J	TYR254
J	ASN307
J	PHE315

---

site_id	EC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PLC J 320

Chain	Residue
J	TRP217

---

site_id	EC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT J 321

Chain	Residue
G	LMT321
J	ALA237
J	THR244

---

site_id	EC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL J 322

Chain	Residue
J	PHE78
J	ARG85

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	740
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---