Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3UU8

The GLIC pentameric Ligand-Gated Ion Channel Loop2-24' mutant reduced in solution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC A 318

Chain	Residue
A	PHE121
A	TYR194
A	TYR254
A	ASN307

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLC A 320

Chain	Residue
A	TYR278
E	TRP217

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLC A 321

Chain	Residue
A	TRP217
B	TYR278

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 322

Chain	Residue
A	VAL81
A	ARG85
A	PHE78

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT A 323

Chain	Residue
B	LMT322

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC B 318

Chain	Residue
B	PHE121
B	TYR194
B	TYR254
B	ASN307

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 320

Chain	Residue
B	PHE78
B	ARG85

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT B 321

Chain	Residue
B	ALA237
B	LMT322

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT B 322

Chain	Residue
A	LMT323
B	LMT321
E	LMT321

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC C 318

Chain	Residue
C	PHE121
C	TYR194
C	ILE202
C	TYR254
C	ASN307

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLC C 320

Chain	Residue
C	TRP217
D	TYR278

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLC C 321

Chain	Residue
B	TRP217
C	TYR278

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 322

Chain	Residue
C	PHE78

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT C 323

Chain	Residue
C	ALA237
C	ILE240

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC D 318

Chain	Residue
D	PHE121
D	TYR194
D	TYR254
D	ASN307

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PLC D 320

Chain	Residue
D	TRP217
E	TYR278

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 321

Chain	Residue
D	PHE78
D	VAL81

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT D 322

Chain	Residue
D	ALA237

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PLC E 318

Chain	Residue
E	PHE121
E	TYR194
E	ILE202
E	LEU206
E	TYR254
E	ASN307

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 320

Chain	Residue
E	PHE78

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT E 321

Chain	Residue
B	LMT322
E	ALA237

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)