Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE ZPZ A 401 |
| Chain | Residue |
| A | GLY11 |
| A | THR72 |
| A | GLN73 |
| A | PHE108 |
| A | TRP115 |
| A | TYR198 |
| A | ASP228 |
| A | SER229 |
| A | GLY230 |
| A | THR231 |
| A | THR232 |
| A | GLN12 |
| A | ASN233 |
| A | ARG235 |
| A | ARG307 |
| A | SER325 |
| A | ALA335 |
| A | URE411 |
| A | HOH762 |
| A | HOH804 |
| A | GLY13 |
| A | TYR14 |
| A | LEU30 |
| A | ASP32 |
| A | GLY34 |
| A | PRO70 |
| A | TYR71 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | TYR51 |
| A | GLN53 |
| A | GLN55 |
| A | LYS218 |
| A | HOH638 |
| A | HOH701 |
| A | HOH731 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | URE406 |
| A | HOH780 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 404 |
| Chain | Residue |
| A | ARG235 |
| A | SER327 |
| A | SER328 |
| A | THR329 |
| A | HOH720 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE URE A 405 |
| Chain | Residue |
| A | ASP62 |
| A | ARG64 |
| A | LEU213 |
| A | MET215 |
| A | HOH662 |
| A | HOH773 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE URE A 406 |
| Chain | Residue |
| A | ARG61 |
| A | ASP62 |
| A | SO4403 |
| A | HOH574 |
| A | HOH597 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE URE A 407 |
| Chain | Residue |
| A | VAL67 |
| A | TYR68 |
| A | ARG128 |
| A | PRO129 |
| A | TRP189 |
| A | HOH625 |
| A | HOH728 |
| A | HOH764 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE URE A 408 |
| Chain | Residue |
| A | PHE-1 |
| A | SER22 |
| A | SER58 |
| A | PRO147 |
| A | GLY177 |
| A | HOH590 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE URE A 409 |
| Chain | Residue |
| A | TYR198 |
| A | LYS224 |
| A | THR329 |
| A | VAL332 |
| A | HOH647 |
| A | HOH745 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE URE A 410 |
| Chain | Residue |
| A | HOH568 |
| A | HOH628 |
| A | HOH775 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE URE A 411 |
| Chain | Residue |
| A | ZPZ401 |
| A | HOH586 |
| A | HOH720 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 412 |
| Chain | Residue |
| A | SER22 |
| A | PRO23 |
| A | PRO91 |
| A | ASN92 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 413 |
| Chain | Residue |
| A | THR72 |
| A | THR231 |
| A | ARG235 |
| A | HOH647 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE29-VAL40 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
