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3UPZ

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005509molecular_functioncalcium ion binding
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
A0016020cellular_componentmembrane
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE B5A A 1
ChainResidue
AHOH11
ALEU181
ALEU57
AVAL65
AALA78
AMET112
AGLU129
ATYR131
AGLU135
AGLU178

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL
ChainResidueDetails
AASP368-LEU380
AASP415-PHE427
AASP451-LEU463
AASP485-PHE497

site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGSFGEVIlCkdkitgqe..........CAVK
ChainResidueDetails
ALEU57-LYS80

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNLLL
ChainResidueDetails
AILE170-LEU182

227561

PDB entries from 2024-11-20

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