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3UPH

Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PO4 A 577
ChainResidue
AARG505
AVAL530
AARG531
ATHR532
AHOH632
AHOH670
AHOH870
AHOH999
AHOH1094

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 0C1 A 578
ChainResidue
APHE193
AARG200
AASN316
ACYS366
ASER367
AGLY410
AASN411
AMET414
ATYR415
AGLN446
AILE447
ATYR448
AGLY449
ASER556
AHOH691
AHOH751
AHOH963
AHOH1099

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 0C1 B 577
ChainResidue
BPHE193
BASN316
BCYS366
BSER367
BGLY410
BASN411
BMET414
BTYR415
BGLN446
BILE447
BTYR448
BGLY449
BSER556
BHOH894
BHOH4001

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-11-06

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