Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3UOM

Ca2+ complex of Human skeletal calsequestrin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005783	cellular_component	endoplasmic reticulum
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0007519	biological_process	skeletal muscle tissue development
A	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
A	0014802	cellular_component	terminal cisterna
A	0014804	cellular_component	terminal cisterna lumen
A	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A	0014870	biological_process	response to muscle inactivity
A	0014894	biological_process	response to denervation involved in regulation of muscle adaptation
A	0016529	cellular_component	sarcoplasmic reticulum
A	0030016	cellular_component	myofibril
A	0030018	cellular_component	Z disc
A	0030315	cellular_component	T-tubule
A	0031674	cellular_component	I band
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0033018	cellular_component	sarcoplasmic reticulum lumen
A	0042383	cellular_component	sarcolemma
A	0042802	molecular_function	identical protein binding
A	0045214	biological_process	sarcomere organization
A	0046872	molecular_function	metal ion binding
A	0051258	biological_process	protein polymerization
A	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
A	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
A	1901341	biological_process	positive regulation of store-operated calcium channel activity
A	2001256	biological_process	regulation of store-operated calcium entry
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005783	cellular_component	endoplasmic reticulum
B	0005790	cellular_component	smooth endoplasmic reticulum
B	0007519	biological_process	skeletal muscle tissue development
B	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
B	0014802	cellular_component	terminal cisterna
B	0014804	cellular_component	terminal cisterna lumen
B	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B	0014870	biological_process	response to muscle inactivity
B	0014894	biological_process	response to denervation involved in regulation of muscle adaptation
B	0016529	cellular_component	sarcoplasmic reticulum
B	0030016	cellular_component	myofibril
B	0030018	cellular_component	Z disc
B	0030315	cellular_component	T-tubule
B	0031674	cellular_component	I band
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0033018	cellular_component	sarcoplasmic reticulum lumen
B	0042383	cellular_component	sarcolemma
B	0042802	molecular_function	identical protein binding
B	0045214	biological_process	sarcomere organization
B	0046872	molecular_function	metal ion binding
B	0051258	biological_process	protein polymerization
B	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
B	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
B	1901341	biological_process	positive regulation of store-operated calcium channel activity
B	2001256	biological_process	regulation of store-operated calcium entry
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005783	cellular_component	endoplasmic reticulum
C	0005790	cellular_component	smooth endoplasmic reticulum
C	0007519	biological_process	skeletal muscle tissue development
C	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
C	0014802	cellular_component	terminal cisterna
C	0014804	cellular_component	terminal cisterna lumen
C	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C	0014870	biological_process	response to muscle inactivity
C	0014894	biological_process	response to denervation involved in regulation of muscle adaptation
C	0016529	cellular_component	sarcoplasmic reticulum
C	0030016	cellular_component	myofibril
C	0030018	cellular_component	Z disc
C	0030315	cellular_component	T-tubule
C	0031674	cellular_component	I band
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0033018	cellular_component	sarcoplasmic reticulum lumen
C	0042383	cellular_component	sarcolemma
C	0042802	molecular_function	identical protein binding
C	0045214	biological_process	sarcomere organization
C	0046872	molecular_function	metal ion binding
C	0051258	biological_process	protein polymerization
C	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
C	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
C	1901341	biological_process	positive regulation of store-operated calcium channel activity
C	2001256	biological_process	regulation of store-operated calcium entry
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005783	cellular_component	endoplasmic reticulum
D	0005790	cellular_component	smooth endoplasmic reticulum
D	0007519	biological_process	skeletal muscle tissue development
D	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
D	0014802	cellular_component	terminal cisterna
D	0014804	cellular_component	terminal cisterna lumen
D	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D	0014870	biological_process	response to muscle inactivity
D	0014894	biological_process	response to denervation involved in regulation of muscle adaptation
D	0016529	cellular_component	sarcoplasmic reticulum
D	0030016	cellular_component	myofibril
D	0030018	cellular_component	Z disc
D	0030315	cellular_component	T-tubule
D	0031674	cellular_component	I band
D	0033017	cellular_component	sarcoplasmic reticulum membrane
D	0033018	cellular_component	sarcoplasmic reticulum lumen
D	0042383	cellular_component	sarcolemma
D	0042802	molecular_function	identical protein binding
D	0045214	biological_process	sarcomere organization
D	0046872	molecular_function	metal ion binding
D	0051258	biological_process	protein polymerization
D	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
D	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
D	1901341	biological_process	positive regulation of store-operated calcium channel activity
D	2001256	biological_process	regulation of store-operated calcium entry
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005783	cellular_component	endoplasmic reticulum
E	0005790	cellular_component	smooth endoplasmic reticulum
E	0007519	biological_process	skeletal muscle tissue development
E	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
E	0014802	cellular_component	terminal cisterna
E	0014804	cellular_component	terminal cisterna lumen
E	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
E	0014870	biological_process	response to muscle inactivity
E	0014894	biological_process	response to denervation involved in regulation of muscle adaptation
E	0016529	cellular_component	sarcoplasmic reticulum
E	0030016	cellular_component	myofibril
E	0030018	cellular_component	Z disc
E	0030315	cellular_component	T-tubule
E	0031674	cellular_component	I band
E	0033017	cellular_component	sarcoplasmic reticulum membrane
E	0033018	cellular_component	sarcoplasmic reticulum lumen
E	0042383	cellular_component	sarcolemma
E	0042802	molecular_function	identical protein binding
E	0045214	biological_process	sarcomere organization
E	0046872	molecular_function	metal ion binding
E	0051258	biological_process	protein polymerization
E	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
E	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
E	1901341	biological_process	positive regulation of store-operated calcium channel activity
E	2001256	biological_process	regulation of store-operated calcium entry
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005783	cellular_component	endoplasmic reticulum
F	0005790	cellular_component	smooth endoplasmic reticulum
F	0007519	biological_process	skeletal muscle tissue development
F	0014701	cellular_component	junctional sarcoplasmic reticulum membrane
F	0014802	cellular_component	terminal cisterna
F	0014804	cellular_component	terminal cisterna lumen
F	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
F	0014870	biological_process	response to muscle inactivity
F	0014894	biological_process	response to denervation involved in regulation of muscle adaptation
F	0016529	cellular_component	sarcoplasmic reticulum
F	0030016	cellular_component	myofibril
F	0030018	cellular_component	Z disc
F	0030315	cellular_component	T-tubule
F	0031674	cellular_component	I band
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0033018	cellular_component	sarcoplasmic reticulum lumen
F	0042383	cellular_component	sarcolemma
F	0042802	molecular_function	identical protein binding
F	0045214	biological_process	sarcomere organization
F	0046872	molecular_function	metal ion binding
F	0051258	biological_process	protein polymerization
F	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
F	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
F	1901341	biological_process	positive regulation of store-operated calcium channel activity
F	2001256	biological_process	regulation of store-operated calcium entry

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MRD A 401

Chain	Residue
A	TRP299

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 402

Chain	Residue
A	ASP275
A	ASN276
A	THR277
A	GLU278
A	ASN279

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 403

Chain	Residue
A	GLU340
A	GLU344
A	HOH658
A	ASN276
A	ASN279
A	LEU282

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD A 404

Chain	Residue
A	GLU143
A	GLU257
A	LEU266
A	LYS270

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 405

Chain	Residue
A	ASP275
A	ALA336
A	GLU337
A	GLU340
A	HOH545

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD A 406

Chain	Residue
A	TYR37
A	HIS38
A	GLU54
A	GLU55
A	LEU58
A	ASP93
A	SER94
A	PHE110

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 407

Chain	Residue
A	ASP13
A	ARG14
A	VAL15
A	ILE16
A	ASN17

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 408

Chain	Residue
A	ASP306
A	SER308
A	HOH617
A	HOH659
B	HOH577

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 409

Chain	Residue
A	ASP259
A	ASP261
A	HOH551
A	HOH652
B	GLU128

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 410

Chain	Residue
A	ASP113
A	HOH601
A	HOH645
B	ASP113
B	HOH563

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 411

Chain	Residue
A	ASP245
A	ASP247
A	ILE249
A	HOH564
A	HOH585
A	HOH638

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 412

Chain	Residue
A	GLU102
A	VAL103
A	HOH577
A	HOH595
A	HOH697

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 413

Chain	Residue
A	ASP261
A	GLU264
A	ASP332
B	GLU135
B	HOH680

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 414

Chain	Residue
A	ASN17
A	VAL18
A	ASP80
A	HOH695

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 415

Chain	Residue
A	THR189
A	GLU194
A	HOH508
A	HOH535
A	HOH615
A	HOH675
A	HOH696

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 416

Chain	Residue
A	ASP210
A	PRO212
A	GLU217
A	HOH649
F	HOH679

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 417

Chain	Residue
A	GLU199
A	THR229
A	HOH502
A	HOH506
A	HOH532
A	HOH559

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 418

Chain	Residue
A	GLU337
A	GLU340
A	HOH516
A	HOH552
A	HOH556
F	ASP101
F	HOH778

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 419

Chain	Residue
F	GLU102
F	GLU169
A	GLU337
A	ASP341
A	HOH549
A	HOH609
A	HOH610

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 420

Chain	Residue
A	ASP345
A	HOH515
A	HOH530
A	HOH599
F	ASP165
F	HOH618
F	HOH759

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 421

Chain	Residue
A	GLU128
A	LEU129
A	GLU135
A	HOH539
B	ASP261

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD B 401

Chain	Residue
A	LEU4
B	MET238
B	TRP242
B	TRP299

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD B 402

Chain	Residue
B	ASP275
B	ASN276
B	THR277
B	GLU278
B	ASN279

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD B 403

Chain	Residue
B	ASN276
B	ASN279
B	GLU340
B	GLU344

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD B 404

Chain	Residue
B	ARG226
B	ARG231
B	SER237
B	THR241

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD B 405

Chain	Residue
B	GLU143
B	GLU257
B	LEU266
B	LYS270

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD B 406

Chain	Residue
B	ALA271
B	SER335
B	ALA336
B	HOH623
B	HOH631

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD B 407

Chain	Residue
B	LEU36
B	HIS38
B	GLU54
B	ASP93
B	SER94
B	PHE110

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 408

Chain	Residue
A	ASP261
B	GLU128
B	LEU129
B	GLU135
B	HOH613

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 409

Chain	Residue
A	GLU256
B	GLU124
B	HOH651
B	HOH666
B	HOH684

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 410

Chain	Residue
B	ASP306
B	SER308
B	HOH629
B	HOH653
B	HOH662
B	HOH681

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 411

Chain	Residue
A	GLU128
A	HOH619
B	ASP259
B	ASP261
B	HOH598

site_id	DC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CA B 412

Chain	Residue
A	ASP113
A	HOH698
B	GLU109
B	SER111
B	ASP113
B	THR114
B	HOH621
B	HOH634

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 413

Chain	Residue
B	ASP245
B	ASP247
B	ILE249
B	HOH601
B	HOH607
B	HOH619

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 414

Chain	Residue
B	GLU102
B	VAL103
B	HOH605
B	HOH628
B	HOH676
B	HOH683

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 415

Chain	Residue
A	GLU135
A	HOH620
B	ASP261
B	GLU264
B	ASP332

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 416

Chain	Residue
B	ASN17
B	VAL18
B	ASP80
B	HOH615

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 417

Chain	Residue
B	THR189
B	HOH512
B	HOH597
B	HOH643
B	HOH668
B	HOH682

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 418

Chain	Residue
B	ASP210
B	PRO212
B	GLU217
B	HOH532
B	HOH541

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 419

Chain	Residue
B	GLU199
B	THR229
B	HOH509
B	HOH510
B	HOH513
B	HOH543

site_id	EC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 420

Chain	Residue
B	GLU337
B	GLU340
B	HOH539
C	ASP101
C	HOH502
C	HOH507
C	HOH594

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 421

Chain	Residue
B	GLU337
B	ASP341
C	GLU169
C	HOH554
C	HOH571
C	HOH589

site_id	EC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 422

Chain	Residue
B	ASP345
B	HOH547
B	HOH548
C	ASP165
C	HOH542
C	HOH580
C	HOH593

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MRD C 401

Chain	Residue
C	MET238
C	TRP299

site_id	EC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD C 402

Chain	Residue
C	GLN274
C	ASP275
C	ASN276
C	THR277
C	GLU278
C	ASN279

site_id	FC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD C 403

Chain	Residue
C	ASN279
C	GLU344
C	HOH679

site_id	FC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD C 404

Chain	Residue
C	ASN316
C	ASP321

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD C 405

Chain	Residue
C	GLU143
C	GLU257
C	LEU266

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD C 407

Chain	Residue
C	ASP13
C	ILE16
C	ASN17

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 408

Chain	Residue
C	ASP306
C	SER308
C	HOH642
C	HOH704
C	HOH713

site_id	FC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 409

Chain	Residue
C	ASP259
C	ASP261
C	HOH567
C	HOH637
D	GLU128

site_id	FC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 410

Chain	Residue
C	SER111
C	ASP113
C	HOH555
C	HOH608
C	HOH610
D	ASP113

site_id	FC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 411

Chain	Residue
C	ASP245
C	ASP247
C	ILE249
C	HOH609
C	HOH634
C	HOH645

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 412

Chain	Residue
C	GLU102
C	VAL103
C	HOH652
C	HOH714

site_id	GC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 413

Chain	Residue
C	ASP261
C	GLU264
C	ASP332
C	HOH659
D	GLU135

site_id	GC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 414

Chain	Residue
C	ASN17
C	VAL18
C	ASP80
C	HOH706
C	HOH711

site_id	GC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 415

Chain	Residue
C	THR189
C	GLU194
C	HOH585
C	HOH602
C	HOH626
C	HOH646
C	HOH689

site_id	GC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 416

Chain	Residue
C	ASP210
C	PRO212
C	GLU217
C	HOH591
C	HOH600
C	HOH630

site_id	GC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 417

Chain	Residue
C	GLU199
C	THR229
C	HOH503
C	HOH512
C	HOH522
C	HOH596

site_id	GC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 418

Chain	Residue
B	ASP101
B	HOH654
C	GLU337
C	GLU340
C	HOH506
C	HOH524
C	HOH528

site_id	GC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 419

Chain	Residue
B	GLU169
B	HOH633
C	GLU337
C	ASP341
C	HOH575
C	HOH577

site_id	GC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 420

Chain	Residue
B	ASP165
C	ASP345
C	HOH511
C	HOH538
C	HOH557
C	HOH561
C	HOH574

site_id	GC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 421

Chain	Residue
C	GLU128
C	LEU129
C	GLU135
C	HOH592
D	ASP261

site_id	HC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 422

Chain	Residue
C	ASP121
C	HOH699
D	HOH619
D	HOH642

site_id	HC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MRD D 401

Chain	Residue
D	TRP242
D	TRP299

site_id	HC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD D 402

Chain	Residue
D	ASP275
D	ASN276
D	THR277
D	GLU278

site_id	HC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD D 403

Chain	Residue
D	ASN279
D	GLU340
D	GLU344
D	HOH654

site_id	HC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MRD D 404

Chain	Residue
D	ASN316
D	ASP321

site_id	HC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD D 405

Chain	Residue
D	GLU143
D	GLU257
D	LEU266
D	LYS270

site_id	HC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD D 406

Chain	Residue
D	ALA271
D	ASP275
D	GLU337
D	GLU340

site_id	HC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD D 407

Chain	Residue
D	LEU36
D	GLU54
D	GLU55
D	PHE110

site_id	HC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 408

Chain	Residue
C	ASP261
D	GLU128
D	LEU129
D	GLU135
D	HOH625

site_id	IC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 409

Chain	Residue
D	ASP306
D	SER308
D	HOH609
D	HOH628
D	HOH634
D	HOH681
D	HOH704

site_id	IC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 410

Chain	Residue
C	GLU128
C	HOH695
D	ASP259
D	ASP261
D	HOH570
D	HOH632

site_id	IC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 411

Chain	Residue
C	ASP113
D	ASP113
D	HOH501
D	HOH502
D	HOH595
D	HOH699

site_id	IC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 412

Chain	Residue
D	ASP245
D	ASP247
D	ILE249
D	HOH521
D	HOH534
D	HOH623

site_id	IC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 413

Chain	Residue
D	GLU102
D	VAL103
D	HOH600
D	HOH674

site_id	IC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 414

Chain	Residue
C	GLU135
C	HOH556
D	ASP261
D	GLU264
D	ASP332

site_id	IC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 415

Chain	Residue
D	ASN17
D	VAL18
D	ASP80
D	HOH707

site_id	IC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 416

Chain	Residue
D	THR189
D	HOH565
D	HOH582
D	HOH627
D	HOH639
D	HOH647

site_id	IC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 417

Chain	Residue
D	ASP210
D	PRO212
D	GLU217
D	HOH506
D	HOH587

site_id	JC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 418

Chain	Residue
D	GLU199
D	THR229
D	HOH512
D	HOH545
D	HOH572
D	HOH578

site_id	JC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 419

Chain	Residue
D	GLU337
D	GLU340
D	HOH553
D	HOH571
D	HOH574
E	ASP101

site_id	JC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 420

Chain	Residue
D	GLU337
D	ASP341
D	HOH626
E	GLU169
E	HOH555
E	HOH561

site_id	JC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 421

Chain	Residue
D	ASP345
D	HOH519
D	HOH541
D	HOH568
D	HOH613
E	ASP165
E	HOH558

site_id	JC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 422

Chain	Residue
D	ASP165
D	HOH573
D	HOH580
D	HOH652
E	ASP345
E	HOH512
E	HOH520

site_id	JC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MRD E 401

Chain	Residue
E	MET238
E	TRP299

site_id	JC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD E 402

Chain	Residue
E	GLN274
E	ASP275
E	ASN276
E	THR277
E	GLU278
E	ASN279

site_id	JC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD E 403

Chain	Residue
E	ASN276
E	ASN279
E	GLU340
E	GLU344

site_id	JC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MRD E 404

Chain	Residue
E	ASN316

site_id	KC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD E 405

Chain	Residue
E	GLU143
E	GLU257
E	PHE263
E	LEU266
E	LYS270

site_id	KC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD E 406

Chain	Residue
E	ALA271
E	ASP275
E	ALA336
E	HOH513
E	HOH578
E	HOH628

site_id	KC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 407

Chain	Residue
E	ASP306
E	SER308
E	HOH584
E	HOH635
E	HOH642
E	HOH682

site_id	KC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 408

Chain	Residue
E	ASP259
E	ASP261
E	HOH585
E	HOH587
F	GLU128

site_id	KC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 409

Chain	Residue
E	ASP113
E	HOH589
E	HOH609
E	HOH627
E	HOH701
F	ASP113

site_id	KC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 410

Chain	Residue
E	ASP245
E	ASP247
E	ILE249
E	HOH567
E	HOH588
E	HOH696

site_id	KC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 411

Chain	Residue
E	GLU102
E	VAL103
E	HOH590
E	HOH653

site_id	KC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 412

Chain	Residue
E	ASP261
E	GLU264
E	ASP332
E	HOH691
F	GLU135
F	HOH745

site_id	KC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 413

Chain	Residue
E	ASN17
E	VAL18
E	ASP80
E	HOH699

site_id	LC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 414

Chain	Residue
E	THR189
E	HOH531
E	HOH570
E	HOH581
E	HOH700
E	HOH713

site_id	LC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 415

Chain	Residue
E	ASP210
E	PRO212
E	GLU217
E	HOH548
E	HOH573
E	HOH649

site_id	LC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 416

Chain	Residue
E	GLU199
E	THR229
E	HOH508
E	HOH519
E	HOH523
E	HOH632

site_id	LC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 417

Chain	Residue
D	ASP101
D	HOH528
E	GLU337
E	GLU340
E	HOH525
E	HOH545

site_id	LC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 418

Chain	Residue
D	GLU169
D	HOH523
D	HOH633
D	HOH665
E	GLU337
E	ASP341

site_id	LC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 419

Chain	Residue
E	GLU128
E	LEU129
E	GLU135
E	HOH630
F	ASP261

site_id	LC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD F 501

Chain	Residue
F	MET238
F	TRP242
F	TRP299

site_id	LC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD F 502

Chain	Residue
F	ASP275
F	ASN276
F	THR277
F	GLU278
F	ASN279
F	HOH786

site_id	LC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD F 503

Chain	Residue
F	ASN279
F	LEU282
F	GLU344
F	HOH624

site_id	MC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD F 504

Chain	Residue
F	ASN316
F	ASP321

site_id	MC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD F 505

Chain	Residue
F	GLU143
F	GLU257
F	PHE263
F	LEU266
F	LYS270

site_id	MC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD F 506

Chain	Residue
F	ASP275
F	HOH610
F	HOH639

site_id	MC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD F 507

Chain	Residue
F	LEU36
F	HIS38
F	GLU54
F	ASP93
F	SER94

site_id	MC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD F 508

Chain	Residue
F	ASP13
F	ARG14
F	VAL15
F	ILE16
F	ASN17

site_id	MC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 509

Chain	Residue
E	ASP261
F	GLU128
F	LEU129
F	GLU135
F	HOH627

site_id	MC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 510

Chain	Residue
F	ASP306
F	SER308
F	HOH739
F	HOH769

site_id	MC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 511

Chain	Residue
E	GLU128
F	ASP259
F	ASP261
F	HOH642
F	HOH748

site_id	MC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 512

Chain	Residue
E	ASP113
E	HOH575
F	ASP113
F	HOH655
F	HOH774

site_id	NC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 513

Chain	Residue
F	ASP245
F	ASP247
F	ILE249
F	HOH672
F	HOH714
F	HOH768

site_id	NC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 514

Chain	Residue
F	GLU102
F	VAL103
F	HOH706
F	HOH708

site_id	NC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 515

Chain	Residue
E	GLU135
E	HOH646
F	ASP261
F	GLU264
F	ASP332
F	HOH790

site_id	NC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 516

Chain	Residue
F	ASN17
F	VAL18
F	ASP80
F	HOH788

site_id	NC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA F 517

Chain	Residue
F	THR189
F	GLU194
F	HOH634
F	HOH652
F	HOH663
F	HOH695
F	HOH703

site_id	NC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 518

Chain	Residue
F	ASP210
F	PRO212
F	GLU217
F	HOH635
F	HOH641
F	HOH749

site_id	NC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 519

Chain	Residue
F	GLU199
F	THR229
F	HOH601
F	HOH607
F	HOH612
F	HOH631

site_id	NC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA F 520

Chain	Residue
A	ASP101
A	HOH558
F	GLU337
F	GLU340
F	HOH608
F	HOH675
F	HOH678

site_id	NC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 521

Chain	Residue
A	HOH657
F	GLU337
F	ASP341
F	HOH603
F	HOH661
F	HOH671

site_id	OC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA F 522

Chain	Residue
A	ASP165
A	HOH554
F	ASP345
F	HOH604
F	HOH616
F	HOH647
F	HOH705

Functional Information from PROSITE/UniProt

site_id	PS00863
Number of Residues	15
Details	CALSEQUESTRIN_1 Calsequestrin signature 1. QEGLDFPeYDGvDRV

Chain	Residue	Details
A	GLN1-VAL15

site_id	PS00864
Number of Residues	20
Details	CALSEQUESTRIN_2 Calsequestrin signature 2. ELEDWLEDVLeGeINTEDDD

Chain	Residue	Details
A	GLU338-ASP357

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P19633","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19633","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P19633","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)