3UO9
Crystal Structure of Human GAC in Complex with Glutamate and BPTES
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004359 | molecular_function | glutaminase activity |
| A | 0006541 | biological_process | glutamine metabolic process |
| B | 0004359 | molecular_function | glutaminase activity |
| B | 0006541 | biological_process | glutamine metabolic process |
| C | 0004359 | molecular_function | glutaminase activity |
| C | 0006541 | biological_process | glutamine metabolic process |
| D | 0004359 | molecular_function | glutaminase activity |
| D | 0006541 | biological_process | glutamine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details |
| Chain | Residue |
| A | LEU434 |
| C | ASN532 |
| C | HOH720 |
| A | ALA435 |
| A | GLY437 |
| A | PRO450 |
| A | VAL453 |
| A | ARG454 |
| A | LEU457 |
| A | HOH673 |
| C | TYR530 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details |
| Chain | Residue |
| A | GLU383 |
| A | ASP386 |
| A | PHE389 |
| B | TYR393 |
| B | LYS396 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details |
| Chain | Residue |
| A | LYS320 |
| A | LEU321 |
| A | PHE322 |
| A | LEU323 |
| A | ASP327 |
| A | TYR394 |
| B | LYS320 |
| B | LEU321 |
| B | PHE322 |
| B | LEU323 |
| B | ASN324 |
| B | GLU325 |
| B | TYR394 |
| D | ARG317 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details |
| Chain | Residue |
| A | ARG317 |
| C | LYS320 |
| C | LEU321 |
| C | PHE322 |
| C | LEU323 |
| C | ASN324 |
| C | ASP327 |
| C | TYR394 |
| D | LYS320 |
| D | LEU321 |
| D | PHE322 |
| D | LEU323 |
| D | ASN324 |
| D | GLU325 |
| D | TYR394 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details |
| Chain | Residue |
| A | SER237 |
| A | HIS516 |
| A | ASP520 |
| C | SER237 |
| C | ASP520 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details |
| Chain | Residue |
| B | TYR530 |
| B | ASN532 |
| D | LEU434 |
| D | ALA435 |
| D | GLY437 |
| D | PRO450 |
| D | VAL453 |
| D | ARG454 |
| D | LEU457 |
| D | HOH670 |
| D | HOH692 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Region: {"description":"Highly mobile activation loop","evidences":[{"source":"UniProtKB","id":"D3Z7P3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"D3Z7P3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
