3UMM
Formylglycinamide ribonucleotide amidotransferase from Salmonella typhimurium: Role of the ATP complexation and glutaminase domain in catalytic coupling
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004642 | molecular_function | phosphoribosylformylglycinamidine synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ANP A 2001 |
| Chain | Residue |
| A | HIS219 |
| A | GLY775 |
| A | LYS776 |
| A | ASP777 |
| A | HOH1313 |
| A | HOH1523 |
| A | HOH1542 |
| A | HOH1629 |
| A | PHE222 |
| A | ASP258 |
| A | ASN259 |
| A | LYS292 |
| A | GLU294 |
| A | ASP318 |
| A | ASP502 |
| A | VAL774 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP A 2005 |
| Chain | Residue |
| A | THR386 |
| A | GLY387 |
| A | TYR388 |
| A | PHE389 |
| A | LYS649 |
| A | GLN668 |
| A | PRO676 |
| A | ALA678 |
| A | ASP679 |
| A | GLU718 |
| A | ASN722 |
| A | SER886 |
| A | HOH1320 |
| A | MG2006 |
| A | MG2007 |
| A | MG2008 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 2006 |
| Chain | Residue |
| A | GLU718 |
| A | ADP2005 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 2007 |
| Chain | Residue |
| A | SER886 |
| A | ADP2005 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 2008 |
| Chain | Residue |
| A | ASP679 |
| A | ASN722 |
| A | ASP884 |
| A | ADP2005 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2002 |
| Chain | Residue |
| A | HIS216 |
| A | THR295 |
| A | ASN297 |
| A | LYS409 |
| A | SER778 |
| A | HOH1350 |
| A | HOH1438 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2009 |
| Chain | Residue |
| A | SER12 |
| A | ALA13 |
| A | PHE14 |
| A | ASN998 |
| A | HIS1161 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
