Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3UKF

CRYSTAL STRUCTURE OF UDP-galactopyranose mutase from Aspergillus fumigatus in complex with UDPgalp (reduced)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0008767	molecular_function	UDP-galactopyranose mutase activity
A	0016853	molecular_function	isomerase activity
A	0071555	biological_process	cell wall organization
B	0000166	molecular_function	nucleotide binding
B	0008767	molecular_function	UDP-galactopyranose mutase activity
B	0016853	molecular_function	isomerase activity
B	0071555	biological_process	cell wall organization
C	0000166	molecular_function	nucleotide binding
C	0008767	molecular_function	UDP-galactopyranose mutase activity
C	0016853	molecular_function	isomerase activity
C	0071555	biological_process	cell wall organization
D	0000166	molecular_function	nucleotide binding
D	0008767	molecular_function	UDP-galactopyranose mutase activity
D	0016853	molecular_function	isomerase activity
D	0071555	biological_process	cell wall organization
E	0000166	molecular_function	nucleotide binding
E	0008767	molecular_function	UDP-galactopyranose mutase activity
E	0016853	molecular_function	isomerase activity
E	0071555	biological_process	cell wall organization
F	0000166	molecular_function	nucleotide binding
F	0008767	molecular_function	UDP-galactopyranose mutase activity
F	0016853	molecular_function	isomerase activity
F	0071555	biological_process	cell wall organization
G	0000166	molecular_function	nucleotide binding
G	0008767	molecular_function	UDP-galactopyranose mutase activity
G	0016853	molecular_function	isomerase activity
G	0071555	biological_process	cell wall organization
H	0000166	molecular_function	nucleotide binding
H	0008767	molecular_function	UDP-galactopyranose mutase activity
H	0016853	molecular_function	isomerase activity
H	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GDU A 802

Chain	Residue
A	GLY62
A	TRP167
A	ARG182
A	VAL183
A	ASN207
A	TYR317
A	ARG327
A	TYR419
A	TYR453
A	ASN457
A	HOH559
A	PHE66
A	HOH588
A	FDA600
A	TYR104
A	PRO105
A	PHE106
A	GLN107
A	PHE158
A	MSE159
A	ASN163

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE FDA A 600

Chain	Residue
A	GLY14
A	GLY16
A	PRO17
A	THR18
A	ASP38
A	SER39
A	GLY45
A	LEU46
A	VAL60
A	HIS63
A	VAL64
A	GLY240
A	VAL242
A	GLY418
A	GLY446
A	ARG447
A	GLY456
A	ASN457
A	GLN458
A	SER461
A	HOH516
A	HOH582
A	HOH780
A	GDU802

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1

Chain	Residue
A	ASP85
A	ALA214
A	ARG215

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 511

Chain	Residue
A	ALA476
A	VAL477
H	ARG495

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GDU B 802

Chain	Residue
B	GLY62
B	PHE66
B	TYR104
B	PRO105
B	PHE106
B	GLN107
B	PHE158
B	MSE159
B	ASN163
B	TRP167
B	ARG182
B	VAL183
B	ASN207
B	TYR317
B	ARG327
B	TYR419
B	TYR453
B	ASN457
B	HOH518
B	HOH558
B	HOH593
B	FDA600

site_id	AC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE FDA B 600

Chain	Residue
B	GLY14
B	GLY16
B	PRO17
B	THR18
B	ASP38
B	SER39
B	GLY45
B	LEU46
B	VAL60
B	HIS63
B	VAL64
B	GLY240
B	VAL242
B	GLY418
B	GLY446
B	ARG447
B	GLY456
B	ASN457
B	GLN458
B	SER461
B	HOH541
B	HOH552
B	HOH553
B	HOH770
B	GDU802

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 511

Chain	Residue
B	VAL477
E	ARG495
E	CL511
B	ALA476

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 512

Chain	Residue
B	SER359
B	GLU406

site_id	AC9
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GDU C 802

Chain	Residue
C	GLY62
C	PHE66
C	TYR104
C	PRO105
C	PHE106
C	GLN107
C	PHE158
C	MSE159
C	ASN163
C	TRP167
C	ARG182
C	ASN207
C	TYR317
C	ARG327
C	TYR419
C	TYR453
C	ASN457
C	FDA600
C	HOH765

site_id	BC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FDA C 600

Chain	Residue
C	GLY14
C	GLY16
C	PRO17
C	THR18
C	ASP38
C	SER39
C	GLY45
C	LEU46
C	ALA47
C	VAL60
C	HIS63
C	VAL64
C	GLY240
C	VAL242
C	GLY418
C	GLY446
C	ARG447
C	GLY456
C	ASN457
C	GLN458
C	SER461
C	HOH779
C	GDU802

site_id	BC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDU D 802

Chain	Residue
D	GLY62
D	PHE66
D	TYR104
D	PRO105
D	PHE106
D	GLN107
D	PHE158
D	MSE159
D	ASN163
D	TRP167
D	ARG182
D	ASN207
D	TYR317
D	ARG327
D	TYR419
D	TYR453
D	ASN457
D	HOH567
D	FDA600
D	HOH766

site_id	BC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FDA D 600

Chain	Residue
D	GLY14
D	GLY16
D	PRO17
D	THR18
D	ASP38
D	SER39
D	GLY45
D	LEU46
D	VAL60
D	HIS63
D	VAL64
D	VAL242
D	GLY418
D	GLY446
D	ARG447
D	GLY456
D	ASN457
D	GLN458
D	SER461
D	HOH524
D	GDU802

site_id	BC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDU E 802

Chain	Residue
E	GLY61
E	GLY62
E	PHE66
E	TYR104
E	PRO105
E	PHE106
E	GLN107
E	PHE158
E	MSE159
E	ASN163
E	TRP167
E	ARG182
E	ASN207
E	TYR317
E	ARG327
E	TYR419
E	TYR453
E	ASN457
E	FDA600
E	HOH644

site_id	BC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE FDA E 600

Chain	Residue
E	GLY14
E	GLY16
E	PRO17
E	THR18
E	ASP38
E	SER39
E	GLY45
E	LEU46
E	VAL60
E	HIS63
E	VAL64
E	GLY240
E	VAL242
E	GLY418
E	GLY446
E	ARG447
E	GLY456
E	ASN457
E	GLN458
E	SER461
E	HOH513
E	HOH531
E	HOH574
E	GDU802

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 511

Chain	Residue
B	CL511
E	VAL477

site_id	BC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDU F 802

Chain	Residue
F	GLY62
F	PHE66
F	PRO105
F	PHE106
F	GLN107
F	PHE158
F	MSE159
F	ASN163
F	TRP167
F	ARG182
F	VAL183
F	ASN207
F	TYR317
F	ARG327
F	TYR419
F	TYR453
F	ASN457
F	HOH520
F	FDA600
F	HOH768

site_id	BC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FDA F 600

Chain	Residue
F	GLY14
F	GLY16
F	PRO17
F	THR18
F	ASP38
F	SER39
F	GLY45
F	LEU46
F	VAL60
F	HIS63
F	VAL64
F	VAL242
F	GLY418
F	GLY446
F	ARG447
F	GLY456
F	ASN457
F	GLN458
F	SER461
F	HOH541
F	HOH543
F	HOH553
F	GDU802

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 511

Chain	Residue
C	ARG495
C	HOH530
F	ALA476
F	VAL477

site_id	CC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GDU G 802

Chain	Residue
G	GLY62
G	PHE66
G	PHE106
G	GLN107
G	PHE158
G	MSE159
G	ASN163
G	TRP167
G	ARG182
G	VAL183
G	ASN207
G	TYR317
G	ARG327
G	TYR419
G	TYR453
G	ASN457
G	HOH545
G	HOH563
G	FDA600

site_id	CC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FDA G 600

Chain	Residue
G	GLY14
G	GLY16
G	PRO17
G	THR18
G	ASP38
G	SER39
G	GLY45
G	LEU46
G	VAL60
G	HIS63
G	VAL64
G	VAL242
G	GLY446
G	ARG447
G	GLY456
G	ASN457
G	GLN458
G	SER461
G	HOH526
G	HOH581
G	GDU802

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 511

Chain	Residue
D	VAL477
G	ARG495

site_id	CC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDU H 802

Chain	Residue
H	GLY61
H	GLY62
H	PHE66
H	TYR104
H	PRO105
H	PHE106
H	GLN107
H	PHE158
H	MSE159
H	ASN163
H	TRP167
H	ARG182
H	VAL183
H	ASN207
H	TYR317
H	ARG327
H	TYR419
H	TYR453
H	ASN457
H	FDA600

site_id	CC5
Number of Residues	25
Details	BINDING SITE FOR RESIDUE FDA H 600

Chain	Residue
H	GLY14
H	GLY16
H	PRO17
H	THR18
H	ASP38
H	SER39
H	GLY45
H	LEU46
H	VAL60
H	HIS63
H	VAL64
H	GLY240
H	VAL242
H	MSE269
H	GLU373
H	GLY418
H	GLY446
H	ARG447
H	GLY456
H	ASN457
H	GLN458
H	SER461
H	HOH513
H	HOH778
H	GDU802

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL H 511

Chain	Residue
H	VAL477

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	BINDING: BINDING => ECO:0000269\|PubMed:22294687, ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKA, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UKK, ECO:0007744\|PDB:3UKL, ECO:0007744\|PDB:3UKP, ECO:0007744\|PDB:3UTE

Chain	Residue	Details
A	THR18
B	ASP38
B	LEU46
B	HIS63
B	VAL242
B	GLY456
B	GLN458
B	SER461
C	THR18
C	ASP38
C	LEU46
A	ASP38
C	HIS63
C	VAL242
C	GLY456
C	GLN458
C	SER461
D	THR18
D	ASP38
D	LEU46
D	HIS63
D	VAL242
A	LEU46
D	GLY456
D	GLN458
D	SER461
E	THR18
E	ASP38
E	LEU46
E	HIS63
E	VAL242
E	GLY456
E	GLN458
A	HIS63
E	SER461
F	THR18
F	ASP38
F	LEU46
F	HIS63
F	VAL242
F	GLY456
F	GLN458
F	SER461
G	THR18
A	VAL242
G	ASP38
G	LEU46
G	HIS63
G	VAL242
G	GLY456
G	GLN458
G	SER461
H	THR18
H	ASP38
H	LEU46
A	GLY456
H	HIS63
H	VAL242
H	GLY456
H	GLN458
H	SER461
A	GLN458
A	SER461
B	THR18

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKP

Chain	Residue	Details
A	GLY61
B	GLY61
C	GLY61
D	GLY61
E	GLY61
F	GLY61
G	GLY61
H	GLY61

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKF, ECO:0007744\|PDB:3UKP, ECO:0007744\|PDB:3UKQ

Chain	Residue	Details
A	GLY62
B	GLY62
C	GLY62
D	GLY62
E	GLY62
F	GLY62
G	GLY62
H	GLY62

site_id	SWS_FT_FI4
Number of Residues	56
Details	BINDING: BINDING => ECO:0000269\|PubMed:23036087, ECO:0007744\|PDB:5VWT

Chain	Residue	Details
A	HIS68
B	SER93
B	ASN203
B	TRP315
B	ARG447
B	HIS460
C	HIS68
C	ARG91
C	SER93
C	ASN203
C	TRP315
A	ARG91
C	ARG447
C	HIS460
D	HIS68
D	ARG91
D	SER93
D	ASN203
D	TRP315
D	ARG447
D	HIS460
E	HIS68
A	SER93
E	ARG91
E	SER93
E	ASN203
E	TRP315
E	ARG447
E	HIS460
F	HIS68
F	ARG91
F	SER93
F	ASN203
A	ASN203
F	TRP315
F	ARG447
F	HIS460
G	HIS68
G	ARG91
G	SER93
G	ASN203
G	TRP315
G	ARG447
G	HIS460
A	TRP315
H	HIS68
H	ARG91
H	SER93
H	ASN203
H	TRP315
H	ARG447
H	HIS460
A	ARG447
A	HIS460
B	HIS68
B	ARG91

site_id	SWS_FT_FI5
Number of Residues	64
Details	BINDING: BINDING => ECO:0000269\|PubMed:22294687, ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKF, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UKP, ECO:0007744\|PDB:3UKQ, ECO:0007744\|PDB:3UTH

Chain	Residue	Details
A	TYR104
B	GLN107
B	ASN163
B	TRP167
B	ARG182
B	ASN207
B	TYR419
B	TYR453
C	TYR104
C	GLN107
C	ASN163
A	GLN107
C	TRP167
C	ARG182
C	ASN207
C	TYR419
C	TYR453
D	TYR104
D	GLN107
D	ASN163
D	TRP167
D	ARG182
A	ASN163
D	ASN207
D	TYR419
D	TYR453
E	TYR104
E	GLN107
E	ASN163
E	TRP167
E	ARG182
E	ASN207
E	TYR419
A	TRP167
E	TYR453
F	TYR104
F	GLN107
F	ASN163
F	TRP167
F	ARG182
F	ASN207
F	TYR419
F	TYR453
G	TYR104
A	ARG182
G	GLN107
G	ASN163
G	TRP167
G	ARG182
G	ASN207
G	TYR419
G	TYR453
H	TYR104
H	GLN107
H	ASN163
A	ASN207
H	TRP167
H	ARG182
H	ASN207
H	TYR419
H	TYR453
A	TYR419
A	TYR453
B	TYR104

site_id	SWS_FT_FI6
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UKP

Chain	Residue	Details
A	MSE159
E	TYR162
F	MSE159
F	TYR162
G	MSE159
G	TYR162
H	MSE159
H	TYR162
A	TYR162
B	MSE159
B	TYR162
C	MSE159
C	TYR162
D	MSE159
D	TYR162
E	MSE159

site_id	SWS_FT_FI7
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:22294687, ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UKQ, ECO:0007744\|PDB:3UTH

Chain	Residue	Details
A	TYR317
B	TYR317
C	TYR317
D	TYR317
E	TYR317
F	TYR317
G	TYR317
H	TYR317

site_id	SWS_FT_FI8
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:22294687, ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKF, ECO:0007744\|PDB:3UKH, ECO:0007744\|PDB:3UTH

Chain	Residue	Details
A	ARG327
B	ARG327
C	ARG327
D	ARG327
E	ARG327
F	ARG327
G	ARG327
H	ARG327

site_id	SWS_FT_FI9
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:22334662, ECO:0007744\|PDB:3UKH

Chain	Residue	Details
A	ASN457
B	ASN457
C	ASN457
D	ASN457
E	ASN457
F	ASN457
G	ASN457
H	ASN457

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)