3UJ7
Phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with SAM and PO4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000234 | molecular_function | phosphoethanolamine N-methyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000234 | molecular_function | phosphoethanolamine N-methyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008654 | biological_process | phospholipid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAM A 301 |
| Chain | Residue |
| A | TYR19 |
| A | ASP110 |
| A | ILE111 |
| A | ARG127 |
| A | ASP128 |
| A | ALA129 |
| A | HIS132 |
| A | HOH289 |
| A | HOH313 |
| A | HOH330 |
| A | HOH395 |
| A | ILE36 |
| A | HOH474 |
| A | SER37 |
| A | GLY63 |
| A | ASP85 |
| A | ILE86 |
| A | CYS87 |
| A | ILE90 |
| A | ASN109 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 303 |
| Chain | Residue |
| A | TYR27 |
| A | TYR160 |
| A | TYR175 |
| A | TYR181 |
| A | LYS247 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAM B 302 |
| Chain | Residue |
| B | TYR19 |
| B | ILE36 |
| B | SER37 |
| B | GLY63 |
| B | ASP85 |
| B | ILE86 |
| B | CYS87 |
| B | ILE90 |
| B | ASN109 |
| B | ASP110 |
| B | ILE111 |
| B | ARG127 |
| B | ASP128 |
| B | ALA129 |
| B | HIS132 |
| B | HOH285 |
| B | HOH294 |
| B | HOH305 |
| B | HOH427 |
| B | HOH429 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 304 |
| Chain | Residue |
| B | TYR27 |
| B | TYR160 |
| B | TYR175 |
| B | ARG179 |
| B | TYR181 |
| B | LYS247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"22117061","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22117061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25288796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22117061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22771008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25288796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
