3UJ4
Crystal structure of the apo-inositol 1,4,5-trisphosphate receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| B | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 605 |
| Chain | Residue |
| A | HIS198 |
| A | ASN396 |
| A | LYS424 |
| B | ARG391 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 108 |
| Details | Domain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | Domain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21892169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22286060","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36376291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EAR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21892169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22286060","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3T8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJ0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22286060","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UJ0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P11881","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P11881","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
