Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0006508 | biological_process | proteolysis |
C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
C | 0005576 | cellular_component | extracellular region |
C | 0010466 | biological_process | negative regulation of peptidase activity |
C | 0035899 | biological_process | suppression of blood coagulation in another organism |
C | 0090729 | molecular_function | toxin activity |
D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
D | 0005576 | cellular_component | extracellular region |
D | 0010466 | biological_process | negative regulation of peptidase activity |
D | 0035899 | biological_process | suppression of blood coagulation in another organism |
D | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 801 |
Chain | Residue |
B | ARG712 |
B | TYR713 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 D 101 |
Chain | Residue |
D | THR49 |
D | LYS50 |
D | GLU51 |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
Chain | Residue | Details |
A | LEU599-CYS604 | |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
Chain | Residue | Details |
A | ASP735-VAL746 | |
site_id | PS00280 |
Number of Residues | 19 |
Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FiyGGCegnannFitkeeC |
Chain | Residue | Details |
C | PHE35-CYS53 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Reactive bond for trypsin => ECO:0000250 |
Chain | Residue | Details |
C | ARG17 | |
D | ARG17 | |
A | SER741 | |
B | HIS603 | |
B | ASP646 | |
B | SER741 | |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | SITE: Cleavage; by plasminogen activator |
Chain | Residue | Details |
A | ARG561 | |
B | ARG561 | |
Chain | Residue | Details |
A | SER578 | |
B | SER578 | |
Chain | Residue | Details |
A | SER669 | |
B | SER669 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 425 |
Chain | Residue | Details |
A | HIS603 | proton shuttle (general acid/base) |
A | ASP646 | electrostatic stabiliser, modifies pKa |
A | SER741 | covalent catalysis, proton shuttle (general acid/base) |
A | GLY742 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 425 |
Chain | Residue | Details |
B | HIS603 | proton shuttle (general acid/base) |
B | ASP646 | electrostatic stabiliser, modifies pKa |
B | SER741 | covalent catalysis, proton shuttle (general acid/base) |
B | GLY742 | electrostatic stabiliser |