Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3UII

crystal structure of human Survivin in complex with H3(1-10) peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000228	cellular_component	nuclear chromosome
A	0000278	biological_process	mitotic cell cycle
A	0000281	biological_process	mitotic cytokinesis
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0006915	biological_process	apoptotic process
A	0007052	biological_process	mitotic spindle organization
A	0007059	biological_process	chromosome segregation
A	0007605	biological_process	sensory perception of sound
A	0008017	molecular_function	microtubule binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0015630	cellular_component	microtubule cytoskeleton
A	0019899	molecular_function	enzyme binding
A	0030414	molecular_function	peptidase inhibitor activity
A	0030496	cellular_component	midbody
A	0031267	molecular_function	small GTPase binding
A	0031503	biological_process	protein-containing complex localization
A	0032133	cellular_component	chromosome passenger complex
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0051087	molecular_function	protein-folding chaperone binding
A	0051233	cellular_component	spindle midzone
A	0051256	biological_process	mitotic spindle midzone assembly
A	0051301	biological_process	cell division
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0090307	biological_process	mitotic spindle assembly
A	1901970	biological_process	positive regulation of mitotic sister chromatid separation
A	1902425	biological_process	positive regulation of attachment of mitotic spindle microtubules to kinetochore
A	1903490	biological_process	positive regulation of mitotic cytokinesis
A	1990713	cellular_component	survivin complex
B	0000228	cellular_component	nuclear chromosome
B	0000278	biological_process	mitotic cell cycle
B	0000281	biological_process	mitotic cytokinesis
B	0000775	cellular_component	chromosome, centromeric region
B	0000776	cellular_component	kinetochore
B	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0006915	biological_process	apoptotic process
B	0007052	biological_process	mitotic spindle organization
B	0007059	biological_process	chromosome segregation
B	0007605	biological_process	sensory perception of sound
B	0008017	molecular_function	microtubule binding
B	0008284	biological_process	positive regulation of cell population proliferation
B	0015630	cellular_component	microtubule cytoskeleton
B	0019899	molecular_function	enzyme binding
B	0030414	molecular_function	peptidase inhibitor activity
B	0030496	cellular_component	midbody
B	0031267	molecular_function	small GTPase binding
B	0031503	biological_process	protein-containing complex localization
B	0032133	cellular_component	chromosome passenger complex
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
B	0051087	molecular_function	protein-folding chaperone binding
B	0051233	cellular_component	spindle midzone
B	0051256	biological_process	mitotic spindle midzone assembly
B	0051301	biological_process	cell division
B	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
B	0090307	biological_process	mitotic spindle assembly
B	1901970	biological_process	positive regulation of mitotic sister chromatid separation
B	1902425	biological_process	positive regulation of attachment of mitotic spindle microtubules to kinetochore
B	1903490	biological_process	positive regulation of mitotic cytokinesis
B	1990713	cellular_component	survivin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 341

Chain	Residue
A	CYS57
A	CYS60
A	HIS77
A	CYS84

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 341

Chain	Residue
B	CYS57
B	CYS60
B	HIS77
B	CYS84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Repeat: {"description":"BIR"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17956729","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QFA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Interaction with FBXL7","evidences":[{"source":"PubMed","id":"25778398","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by AURKC","evidences":[{"source":"PubMed","id":"27332895","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	14
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"20826784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CDK1 and CDK15","evidences":[{"source":"PubMed","id":"11069302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24866247","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CK2; in vitro","evidences":[{"source":"PubMed","id":"21252625","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"14610074","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)