3UGJ

Formyl Glycinamide ribonucletide amidotransferase from Salmonella Typhimurum: Role of the ATP complexation and glutaminase domain in catalytic coupling

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 2001

Chain	Residue
A	LYS292
A	GLU294
A	ASP318
A	LYS776
A	HOH1822
A	HOH1867

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 2002

Chain	Residue
A	ASN297
A	HIS298
A	SER778
A	HOH1395
A	HOH1529
A	HOH1624
A	HIS216
A	THR295
A	HIS296

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 2003

Chain	Residue
A	LYS327
A	ARG479
A	ASN1051
A	HIS1053
A	VAL1054
A	HOH1590
A	HOH1633
A	HOH1660

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 2004

Chain	Residue
A	TRP305
A	ARG1159
A	ARG1164
A	HOH1350
A	HOH1374
A	HOH1939
A	HOH1994

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 2009

Chain	Residue
A	HIS216
A	GLY504
A	ALA505
A	LYS776
A	HOH1799
A	HOH1867

---

site_id	AC6
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ADP A 2005

Chain	Residue
A	VAL333
A	THR386
A	GLY387
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	GLN668
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	HOH1297
A	HOH1300
A	HOH1345
A	HOH1388
A	HOH1400
A	HOH1406
A	HOH1451
A	HOH1663
A	MG2006
A	MG2007
A	MG2008
A	HOH2093

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 2006

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP2005

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 2007

Chain	Residue
A	GLU718
A	HOH1297
A	HOH1300
A	ADP2005

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 2008

Chain	Residue
A	HOH1394
A	ADP2005

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	253
Details	Domain: {"description":"Glutamine amidotransferase type-1","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---