3UFX

Thermus aquaticus succinyl-CoA synthetase in complex with GDP-Mn2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
A	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
A	0006099	biological_process	tricarboxylic acid cycle
A	0009361	cellular_component	succinate-CoA ligase complex (ADP-forming)
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
B	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006099	biological_process	tricarboxylic acid cycle
B	0006104	biological_process	succinyl-CoA metabolic process
B	0042709	cellular_component	succinate-CoA ligase complex
B	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
D	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
D	0006099	biological_process	tricarboxylic acid cycle
D	0009361	cellular_component	succinate-CoA ligase complex (ADP-forming)
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
E	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006099	biological_process	tricarboxylic acid cycle
E	0006104	biological_process	succinyl-CoA metabolic process
E	0042709	cellular_component	succinate-CoA ligase complex
E	0046872	molecular_function	metal ion binding
F	0003824	molecular_function	catalytic activity
F	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
F	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
F	0006099	biological_process	tricarboxylic acid cycle
F	0009361	cellular_component	succinate-CoA ligase complex (ADP-forming)
G	0000287	molecular_function	magnesium ion binding
G	0003824	molecular_function	catalytic activity
G	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
G	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006099	biological_process	tricarboxylic acid cycle
G	0006104	biological_process	succinyl-CoA metabolic process
G	0042709	cellular_component	succinate-CoA ligase complex
G	0046872	molecular_function	metal ion binding
H	0003824	molecular_function	catalytic activity
H	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
H	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
H	0006099	biological_process	tricarboxylic acid cycle
H	0009361	cellular_component	succinate-CoA ligase complex (ADP-forming)
I	0000287	molecular_function	magnesium ion binding
I	0003824	molecular_function	catalytic activity
I	0004775	molecular_function	succinate-CoA ligase (ADP-forming) activity
I	0004776	molecular_function	succinate-CoA ligase (GDP-forming) activity
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006099	biological_process	tricarboxylic acid cycle
I	0006104	biological_process	succinyl-CoA metabolic process
I	0042709	cellular_component	succinate-CoA ligase complex
I	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP B 398

Chain	Residue
B	VAL43
B	GLY122
B	ASN190
B	ASP204
B	MN399
B	HOH414
B	HOH422
B	HOH449
B	LYS45
B	GLY52
B	ARG53
B	GLY54
B	ALA93
B	VAL94
B	ILE96
B	GLU99

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN B 399

Chain	Residue
B	ASN190
B	ASP204
B	GDP398

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GDP E 398

Chain	Residue
E	VAL43
E	LYS45
E	GLY52
E	ARG53
E	GLY54
E	ALA93
E	VAL94
E	ILE96
E	GLU99
E	ASN190
E	ASP204
E	MN399
E	HOH685
E	HOH732

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN E 399

Chain	Residue
E	ASN190
E	ASP204
E	GDP398

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP G 398

Chain	Residue
G	VAL43
G	LYS45
G	GLY52
G	ARG53
G	GLY54
G	ALA93
G	VAL94
G	ILE96
G	GLU99
G	ASN190
G	ASP204
G	MN399
G	HOH402
G	HOH733
G	HOH736

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN G 399

Chain	Residue
G	ASN190
G	ASP204
G	GDP398

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GDP I 398

Chain	Residue
I	VAL43
I	LYS45
I	GLY52
I	ARG53
I	GLY54
I	ALA93
I	VAL94
I	ILE96
I	GLU99
I	ASN190
I	ASP204
I	MN399
I	HOH734
I	HOH735

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN I 399

Chain	Residue
I	ASN190
I	ASP204
I	GDP398

---

Functional Information from PROSITE/UniProt

site_id	PS00399
Number of Residues	14
Details	SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GrsApkgk...RMGHAG

Chain	Residue	Details
A	GLY235-GLY248

---

site_id	PS01216
Number of Residues	30
Details	SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGTLTyEaaaalsqaglGttttVGIGGD

Chain	Residue	Details
A	SER151-ASP180

---

site_id	PS01217
Number of Residues	26
Details	SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GnIgiIgNGAGLVmytlDlVnrvgGK

Chain	Residue	Details
B	GLY248-LYS273

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01988","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22751660","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01988","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	904
Details	Domain: {"description":"ATP-grasp","evidences":[{"source":"HAMAP-Rule","id":"MF_00558","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22751660","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00558","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22751660","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00558","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---