3UE9
Crystal structure of Adenylosuccinate synthetase (AMPSase) (purA) from Burkholderia thailandensis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004019 | molecular_function | adenylosuccinate synthase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| A | 0046040 | biological_process | IMP metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004019 | molecular_function | adenylosuccinate synthase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0046040 | biological_process | IMP metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004019 | molecular_function | adenylosuccinate synthase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0016874 | molecular_function | ligase activity |
| C | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| C | 0046040 | biological_process | IMP metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004019 | molecular_function | adenylosuccinate synthase activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| D | 0046040 | biological_process | IMP metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 449 |
| Chain | Residue |
| A | PRO209 |
| A | HOH471 |
| A | HOH794 |
| A | HOH795 |
| A | HOH854 |
| A | HOH855 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 449 |
| Chain | Residue |
| B | HOH511 |
| B | HOH761 |
| B | HOH875 |
| B | PRO209 |
| B | HOH455 |
| B | HOH472 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 449 |
| Chain | Residue |
| A | PHE177 |
| C | ARG127 |
| C | LEU186 |
| C | HOH684 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA C 450 |
| Chain | Residue |
| C | PRO209 |
| C | HOH600 |
| C | HOH663 |
| C | HOH772 |
| C | HOH773 |
| C | HOH774 |
| C | HOH823 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT D 449 |
| Chain | Residue |
| B | ARG154 |
| D | ARG127 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA D 450 |
| Chain | Residue |
| D | PRO209 |
| D | HOH534 |
| D | HOH569 |
| D | HOH791 |
| D | HOH792 |
| D | HOH793 |
| D | HOH1128 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00011 |
| Chain | Residue | Details |
| A | ASP23 | |
| B | ASP23 | |
| C | ASP23 | |
| D | ASP23 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00011 |
| Chain | Residue | Details |
| A | HIS51 | |
| B | HIS51 | |
| C | HIS51 | |
| D | HIS51 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00011 |
| Chain | Residue | Details |
| A | GLY22 | |
| B | ASP23 | |
| B | GLY50 | |
| B | ARG153 | |
| B | SER317 | |
| B | ARG323 | |
| B | LYS349 | |
| B | SER431 | |
| C | GLY22 | |
| C | ASP23 | |
| C | GLY50 | |
| A | ASP23 | |
| C | ARG153 | |
| C | SER317 | |
| C | ARG323 | |
| C | LYS349 | |
| C | SER431 | |
| D | GLY22 | |
| D | ASP23 | |
| D | GLY50 | |
| D | ARG153 | |
| D | SER317 | |
| A | GLY50 | |
| D | ARG323 | |
| D | LYS349 | |
| D | SER431 | |
| A | ARG153 | |
| A | SER317 | |
| A | ARG323 | |
| A | LYS349 | |
| A | SER431 | |
| B | GLY22 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_00011 |
| Chain | Residue | Details |
| A | ASN48 | |
| B | ARG321 | |
| C | ASN48 | |
| C | THR139 | |
| C | GLN234 | |
| C | THR249 | |
| C | ARG321 | |
| D | ASN48 | |
| D | THR139 | |
| D | GLN234 | |
| D | THR249 | |
| A | THR139 | |
| D | ARG321 | |
| A | GLN234 | |
| A | THR249 | |
| A | ARG321 | |
| B | ASN48 | |
| B | THR139 | |
| B | GLN234 | |
| B | THR249 |
