3UE9

Crystal structure of Adenylosuccinate synthetase (AMPSase) (purA) from Burkholderia thailandensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004019	molecular_function	adenylosuccinate synthase activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0016874	molecular_function	ligase activity
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0046040	biological_process	IMP metabolic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004019	molecular_function	adenylosuccinate synthase activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0016874	molecular_function	ligase activity
B	0044208	biological_process	'de novo' AMP biosynthetic process
B	0046040	biological_process	IMP metabolic process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004019	molecular_function	adenylosuccinate synthase activity
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0016874	molecular_function	ligase activity
C	0044208	biological_process	'de novo' AMP biosynthetic process
C	0046040	biological_process	IMP metabolic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004019	molecular_function	adenylosuccinate synthase activity
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0016874	molecular_function	ligase activity
D	0044208	biological_process	'de novo' AMP biosynthetic process
D	0046040	biological_process	IMP metabolic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 449

Chain	Residue
A	PRO209
A	HOH471
A	HOH794
A	HOH795
A	HOH854
A	HOH855

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 449

Chain	Residue
B	HOH511
B	HOH761
B	HOH875
B	PRO209
B	HOH455
B	HOH472

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 449

Chain	Residue
A	PHE177
C	ARG127
C	LEU186
C	HOH684

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 450

Chain	Residue
C	PRO209
C	HOH600
C	HOH663
C	HOH772
C	HOH773
C	HOH774
C	HOH823

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT D 449

Chain	Residue
B	ARG154
D	ARG127

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 450

Chain	Residue
D	PRO209
D	HOH534
D	HOH569
D	HOH791
D	HOH792
D	HOH793
D	HOH1128

---

Functional Information from PROSITE/UniProt

site_id	PS00513
Number of Residues	12
Details	ADENYLOSUCCIN_SYN_2 Adenylosuccinate synthetase active site. GIGPaYedKvgR

Chain	Residue	Details
A	GLY142-ARG153

---

site_id	PS01266
Number of Residues	8
Details	ADENYLOSUCCIN_SYN_1 Adenylosuccinate synthetase GTP-binding site. QWGDEGKG

Chain	Residue	Details
A	GLN20-GLY27

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00011","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00011","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	85
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00011","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	33
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_00011","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---