3UDZ
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from A. thaliana in complex with ADP and IP6.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0010264 | biological_process | myo-inositol hexakisphosphate biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0030643 | biological_process | intracellular phosphate ion homeostasis |
A | 0032942 | molecular_function | inositol tetrakisphosphate 2-kinase activity |
A | 0035299 | molecular_function | inositol pentakisphosphate 2-kinase activity |
A | 0042742 | biological_process | defense response to bacterium |
A | 0046872 | molecular_function | metal ion binding |
A | 0048527 | biological_process | lateral root development |
A | 0050832 | biological_process | defense response to fungus |
A | 0051607 | biological_process | defense response to virus |
A | 0055062 | biological_process | phosphate ion homeostasis |
A | 0102731 | molecular_function | D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0010264 | biological_process | myo-inositol hexakisphosphate biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0030643 | biological_process | intracellular phosphate ion homeostasis |
B | 0032942 | molecular_function | inositol tetrakisphosphate 2-kinase activity |
B | 0035299 | molecular_function | inositol pentakisphosphate 2-kinase activity |
B | 0042742 | biological_process | defense response to bacterium |
B | 0046872 | molecular_function | metal ion binding |
B | 0048527 | biological_process | lateral root development |
B | 0050832 | biological_process | defense response to fungus |
B | 0051607 | biological_process | defense response to virus |
B | 0055062 | biological_process | phosphate ion homeostasis |
B | 0102731 | molecular_function | D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE IHP A 500 |
Chain | Residue |
A | GLY19 |
A | ASN238 |
A | ASP368 |
A | ASP407 |
A | LYS411 |
A | ARG415 |
A | TYR419 |
A | HOH463 |
A | HOH469 |
A | HOH474 |
A | HOH503 |
A | GLY20 |
A | HOH508 |
A | HOH530 |
A | HOH583 |
A | HOH594 |
A | ADP600 |
A | HOH605 |
A | HOH635 |
A | HOH638 |
A | MG700 |
A | MG701 |
A | ALA21 |
A | ARG45 |
A | ARG130 |
A | LYS168 |
A | LYS170 |
A | HIS196 |
A | LYS200 |
site_id | AC2 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE ADP A 600 |
Chain | Residue |
A | GLU18 |
A | GLY19 |
A | GLY20 |
A | ALA21 |
A | ASN22 |
A | VAL24 |
A | ARG40 |
A | ASN147 |
A | ASP148 |
A | HIS149 |
A | GLU166 |
A | ARG241 |
A | MSE372 |
A | ILE406 |
A | ASP407 |
A | IHP500 |
A | HOH535 |
A | HOH556 |
A | HOH568 |
A | MG700 |
A | MG701 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 700 |
Chain | Residue |
A | ASP407 |
A | SER409 |
A | HOH474 |
A | IHP500 |
A | ADP600 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 701 |
Chain | Residue |
A | ASP407 |
A | HOH489 |
A | IHP500 |
A | HOH568 |
A | ADP600 |
site_id | AC5 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE IHP B 500 |
Chain | Residue |
B | GLY19 |
B | GLY20 |
B | ALA21 |
B | ARG45 |
B | ARG130 |
B | LYS168 |
B | LYS170 |
B | HIS196 |
B | LYS200 |
B | ASN238 |
B | ASP368 |
B | ASP407 |
B | LYS411 |
B | ARG415 |
B | TYR419 |
B | HOH469 |
B | HOH473 |
B | HOH476 |
B | HOH487 |
B | HOH495 |
B | HOH499 |
B | HOH519 |
B | HOH562 |
B | HOH587 |
B | ADP600 |
B | HOH621 |
B | MG700 |
B | MG701 |
site_id | AC6 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE ADP B 600 |
Chain | Residue |
B | ARG241 |
B | MSE372 |
B | ILE406 |
B | ASP407 |
B | HOH482 |
B | IHP500 |
B | HOH575 |
B | HOH627 |
B | MG700 |
B | MG701 |
B | GLY19 |
B | GLY20 |
B | ALA21 |
B | ASN22 |
B | VAL24 |
B | VAL38 |
B | ARG40 |
B | ASN147 |
B | ASP148 |
B | HIS149 |
B | GLU166 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 700 |
Chain | Residue |
B | ASP407 |
B | SER409 |
B | HOH499 |
B | IHP500 |
B | ADP600 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 701 |
Chain | Residue |
B | ASP407 |
B | IHP500 |
B | HOH558 |
B | ADP600 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 800 |
Chain | Residue |
B | HIS320 |
B | CYS330 |
B | HIS346 |
B | HOH460 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000305|PubMed:20453199, ECO:0000305|PubMed:22745128 |
Chain | Residue | Details |
A | GLY19 | |
B | ASP407 | |
A | ARG40 | |
A | ASN147 | |
A | GLU166 | |
A | ASP407 | |
B | GLY19 | |
B | ARG40 | |
B | ASN147 | |
B | GLU166 |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000305|PubMed:20453199, ECO:0000305|PubMed:22362712, ECO:0000305|PubMed:22684075, ECO:0000305|PubMed:22745128 |
Chain | Residue | Details |
A | ARG45 | |
B | ARG45 | |
B | ARG130 | |
B | LYS170 | |
B | LYS200 | |
B | ASN238 | |
B | ASP368 | |
B | LYS411 | |
B | ARG415 | |
B | TYR419 | |
A | ARG130 | |
A | LYS170 | |
A | LYS200 | |
A | ASN238 | |
A | ASP368 | |
A | LYS411 | |
A | ARG415 | |
A | TYR419 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:22745128 |
Chain | Residue | Details |
A | ARG241 | |
B | ARG241 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0007744|PDB:2XAL, ECO:0007744|PDB:2XAM, ECO:0007744|PDB:2XAN, ECO:0007744|PDB:2XAO, ECO:0007744|PDB:2XAR, ECO:0007744|PDB:3UDT, ECO:0007744|PDB:3UDZ, ECO:0007744|PDB:4AQK, ECO:0007744|PDB:4AXC, ECO:0007744|PDB:4AXD, ECO:0007744|PDB:4AXE, ECO:0007744|PDB:4AXF, ECO:0007744|PDB:4LV7 |
Chain | Residue | Details |
A | HIS320 | |
A | CYS330 | |
A | HIS346 | |
B | HIS320 | |
B | CYS330 | |
B | HIS346 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0007744|PDB:2XAL, ECO:0007744|PDB:2XAM, ECO:0007744|PDB:2XAN, ECO:0007744|PDB:2XAO, ECO:0007744|PDB:2XAR, ECO:0007744|PDB:3UDT, ECO:0007744|PDB:4AQK, ECO:0007744|PDB:4AXC, ECO:0007744|PDB:4AXD, ECO:0007744|PDB:4AXE, ECO:0007744|PDB:4AXF, ECO:0007744|PDB:4LV7 |
Chain | Residue | Details |
A | CYS333 | |
B | CYS333 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895 |
Chain | Residue | Details |
A | MSE1 | |
B | MSE1 |