Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3UDU

Crystal structure of putative 3-isopropylmalate dehydrogenase from Campylobacter jejuni

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009098	biological_process	L-leucine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0000287	molecular_function	magnesium ion binding
B	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009098	biological_process	L-leucine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
C	0000287	molecular_function	magnesium ion binding
C	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009098	biological_process	L-leucine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0000287	molecular_function	magnesium ion binding
D	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009098	biological_process	L-leucine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0046872	molecular_function	metal ion binding
D	0051287	molecular_function	NAD binding
E	0000287	molecular_function	magnesium ion binding
E	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009098	biological_process	L-leucine biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0046872	molecular_function	metal ion binding
E	0051287	molecular_function	NAD binding
F	0000287	molecular_function	magnesium ion binding
F	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009098	biological_process	L-leucine biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding
G	0000287	molecular_function	magnesium ion binding
G	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0009098	biological_process	L-leucine biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0046872	molecular_function	metal ion binding
G	0051287	molecular_function	NAD binding
H	0000287	molecular_function	magnesium ion binding
H	0003862	molecular_function	3-isopropylmalate dehydrogenase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0009098	biological_process	L-leucine biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0046872	molecular_function	metal ion binding
H	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 359

Chain	Residue
A	ILE112
A	THR117
A	ILE127
A	GLY130
A	VAL131
A	HOH556

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 359

Chain	Residue
B	ASN40
B	LEU63
B	GLN66
E	LYS152
A	ASP50
B	LYS5
B	GLU38

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 359

Chain	Residue
D	ILE112
D	GLU114
D	ILE127
D	GLY130
D	VAL131

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 359

Chain	Residue
E	ILE112
E	ILE127
E	GLY130
E	VAL131
E	HOH909
E	HOH1096

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F 359

Chain	Residue
F	ILE112
F	GLU114
F	ILE127
F	GLY130
F	VAL131
F	HOH796

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 359

Chain	Residue
G	ILE112
G	ILE127
G	GLY130
G	VAL131

Functional Information from PROSITE/UniProt

site_id	PS00470
Number of Residues	20
Details	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLFGDIlSDelAain.GSLGL

Chain	Residue	Details
A	ASN241-LEU260

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01033

Chain	Residue	Details
A	GLY77
B	ARG98
B	ARG108
B	ARG137
B	ASP221
B	ASP245
B	ASP249
B	GLY279
C	GLY77
C	ARG98
C	ARG108
A	ARG98
C	ARG137
C	ASP221
C	ASP245
C	ASP249
C	GLY279
D	GLY77
D	ARG98
D	ARG108
D	ARG137
D	ASP221
A	ARG108
D	ASP245
D	ASP249
D	GLY279
E	GLY77
E	ARG98
E	ARG108
E	ARG137
E	ASP221
E	ASP245
E	ASP249
A	ARG137
E	GLY279
F	GLY77
F	ARG98
F	ARG108
F	ARG137
F	ASP221
F	ASP245
F	ASP249
F	GLY279
G	GLY77
A	ASP221
G	ARG98
G	ARG108
G	ARG137
G	ASP221
G	ASP245
G	ASP249
G	GLY279
H	GLY77
H	ARG98
H	ARG108
A	ASP245
H	ARG137
H	ASP221
H	ASP245
H	ASP249
H	GLY279
A	ASP249
A	GLY279
B	GLY77

site_id	SWS_FT_FI2
Number of Residues	16
Details	SITE: Important for catalysis => ECO:0000255\|HAMAP-Rule:MF_01033

Chain	Residue	Details
A	TYR144
E	LYS189
F	TYR144
F	LYS189
G	TYR144
G	LYS189
H	TYR144
H	LYS189
A	LYS189
B	TYR144
B	LYS189
C	TYR144
C	LYS189
D	TYR144
D	LYS189
E	TYR144

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)