3UCW

Structure of MG2+ bound N-Terminal domain of Calmodulin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
C	0005509	molecular_function	calcium ion binding
D	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 100

Chain	Residue
A	ASP20
A	ASP22
A	ASP24
A	THR26
A	HOH208
A	HOH224

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 101

Chain	Residue
A	HOH211
A	HOH212
A	THR62
A	HOH209
A	HOH210

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 102

Chain	Residue
A	ASP64
A	HOH217
B	ASP64
B	HOH201
B	HOH202
B	HOH212

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 100

Chain	Residue
B	ASP20
B	ASP22
B	ASP24
B	THR26
B	HOH204
B	HOH205

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 101

Chain	Residue
B	THR62
B	HOH207
B	HOH208
B	HOH209
B	HOH217

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 100

Chain	Residue
C	ASP20
C	ASP22
C	ASP24
C	THR26
C	HOH208
C	HOH209

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 101

Chain	Residue
C	THR62
C	HOH204
C	HOH205
C	HOH206
C	HOH216

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 102

Chain	Residue
C	ASP64
C	HOH202
C	HOH203
C	HOH219
C	HOH220
D	ASP64

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 100

Chain	Residue
D	ASP20
D	ASP22
D	ASP24
D	THR26
D	HOH201
D	HOH202

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 101

Chain	Residue
D	THR62
D	HOH203
D	HOH204
D	HOH212
D	HOH230

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
A	ASP20-LEU32
A	ASP56-PHE68

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03

Chain	Residue	Details
A	ASP20
A	GLU67
B	ASP20
B	ASP22
B	ASP24
B	THR26
B	GLU31
B	ASP56
B	ASP58
B	ASN60
B	THR62
A	ASP22
B	GLU67
C	ASP20
C	ASP22
C	ASP24
C	THR26
C	GLU31
C	ASP56
C	ASP58
C	ASN60
C	THR62
A	ASP24
C	GLU67
D	ASP20
D	ASP22
D	ASP24
D	THR26
D	GLU31
D	ASP56
D	ASP58
D	ASN60
D	THR62
A	THR26
D	GLU67
A	GLU31
A	ASP56
A	ASP58
A	ASN60
A	THR62

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	ALA1
B	ALA1
C	ALA1
D	ALA1

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS21
B	LYS21
C	LYS21
D	LYS21

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
A	THR44
B	THR44
C	THR44
D	THR44

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
A	LYS21
B	LYS21
C	LYS21
D	LYS21

---