3UAL
Crystal Structure of 14-3-3 epsilon with Mlf1 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0002753 | biological_process | cytoplasmic pattern recognition receptor signaling pathway |
| A | 0003064 | biological_process | regulation of heart rate by hormone |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004864 | molecular_function | protein phosphatase inhibitor activity |
| A | 0005246 | molecular_function | calcium channel regulator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0007346 | biological_process | regulation of mitotic cell cycle |
| A | 0008104 | biological_process | intracellular protein localization |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019855 | molecular_function | calcium channel inhibitor activity |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019903 | molecular_function | protein phosphatase binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0021762 | biological_process | substantia nigra development |
| A | 0023026 | molecular_function | MHC class II protein complex binding |
| A | 0030007 | biological_process | intracellular potassium ion homeostasis |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0034122 | biological_process | negative regulation of toll-like receptor signaling pathway |
| A | 0034504 | biological_process | protein localization to nucleus |
| A | 0034605 | biological_process | cellular response to heat |
| A | 0035332 | biological_process | positive regulation of hippo signaling |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0035591 | molecular_function | signaling adaptor activity |
| A | 0042308 | biological_process | negative regulation of protein import into nucleus |
| A | 0042470 | cellular_component | melanosome |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042826 | molecular_function | histone deacetylase binding |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0046827 | biological_process | positive regulation of protein export from nucleus |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0050815 | molecular_function | phosphoserine residue binding |
| A | 0051219 | molecular_function | phosphoprotein binding |
| A | 0051480 | biological_process | regulation of cytosolic calcium ion concentration |
| A | 0060306 | biological_process | regulation of membrane repolarization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070972 | biological_process | protein localization to endoplasmic reticulum |
| A | 0086013 | biological_process | membrane repolarization during cardiac muscle cell action potential |
| A | 0086091 | biological_process | regulation of heart rate by cardiac conduction |
| A | 0097110 | molecular_function | scaffold protein binding |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 0140678 | molecular_function | molecular function inhibitor activity |
| A | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
| A | 1905913 | biological_process | negative regulation of calcium ion export across plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TBU A 233 |
| Chain | Residue |
| A | SER156 |
| A | MET160 |
| A | ALA174 |
| A | HOH258 |
| A | HOH293 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TBU A 234 |
| Chain | Residue |
| A | SER156 |
| A | LEU194 |
| A | HOH262 |
| A | HOH339 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE TBU A 235 |
| Chain | Residue |
| A | MET160 |
| A | TYR181 |
| A | ARG190 |
Functional Information from PROSITE/UniProt
| site_id | PS00796 |
| Number of Residues | 11 |
| Details | 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV |
| Chain | Residue | Details |
| A | ARG42-VAL52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with phosphoserine on interacting protein"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62260","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62260","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62260","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22151054","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
