3U9C

Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit with the ATP-competitive inhibitor resorufin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	HIS276
A	SER277
A	LYS279

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	LYS77
A	ARG80
A	ARG155
A	ASN189
A	HOH511

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 403

Chain	Residue
A	ARG278
B	SER277
B	ARG278
A	SER277

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 04G A 404

Chain	Residue
A	VAL66
A	LYS68
A	GLU81
A	PHE113
A	VAL116
A	ASN118
A	ILE174
A	ASP175
A	TRP176

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 405

Chain	Residue
A	ARG19

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 406

Chain	Residue
A	TYR146
A	SER149

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 407

Chain	Residue
A	SER311
A	GLU317

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 408

Chain	Residue
A	ARG280
A	ARG283

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
B	LYS77
B	ARG80
B	ARG155
B	ASN189

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 402

Chain	Residue
A	LYS74
B	TRP33
B	LYS102
B	HOH522

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 403

Chain	Residue
B	ARG280
B	ARG283

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 404

Chain	Residue
B	ARG191
B	LYS198
B	ASN238

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 04G B 405

Chain	Residue
B	VAL66
B	LYS68
B	PHE113
B	VAL116
B	ASN118
B	ASP175

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 406

Chain	Residue
A	GLU282
A	VAL293
B	ASP299
B	LYS303

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 407

Chain	Residue
B	ARG275
B	HIS276
B	SER277
B	LYS279

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK

Chain	Residue	Details
A	LEU45-LYS68

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE152-ILE164

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	570
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---