Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3U8L

Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3570 (1-(5-phenylpyridin-3-yl)-1,4-diazepane)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0043083	cellular_component	synaptic cleft
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0043083	cellular_component	synaptic cleft
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0043083	cellular_component	synaptic cleft
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0043083	cellular_component	synaptic cleft
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0043083	cellular_component	synaptic cleft
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0043083	cellular_component	synaptic cleft
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0043083	cellular_component	synaptic cleft
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0043083	cellular_component	synaptic cleft
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0043083	cellular_component	synaptic cleft
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0043083	cellular_component	synaptic cleft

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 09Q A 211

Chain	Residue
A	TYR89
A	TRP143
A	TYR185
A	TYR192
A	HOH827
B	GLN73
B	ARG104

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 09Q B 211

Chain	Residue
B	TYR185
B	TYR192
B	HOH221
C	GLN73
C	ARG104
C	MET114
B	TYR89
B	TRP143

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 09Q B 212

Chain	Residue
A	TYR89
A	LYS139
A	THR184
B	TRP53
B	ASP160
B	GLU163
B	TYR164

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 09Q B 213

Chain	Residue
B	LEU33
B	LYS34
B	PHE35
B	GLU157
B	ASP161
B	SER162
B	ILE173
B	VAL176
B	GLN178

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 214

Chain	Residue
A	ARG148
B	ARG3
B	ASP72
B	HOH513

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 215

Chain	Residue
B	ARG148
C	ASP72

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 09Q C 211

Chain	Residue
C	TYR89
C	TRP143
C	TYR185
C	TYR192
D	GLN73
D	ARG104
D	MET114
D	HOH233

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 09Q D 211

Chain	Residue
D	TYR89
D	TRP143
D	TYR185
D	TYR192
D	HOH216
E	ARG104
E	LEU112
E	MET114

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 09Q E 211

Chain	Residue
A	GLN73
A	ARG104
A	LEU112
A	MET114
E	TYR89
E	TRP143
E	TYR185
E	CYS188
E	TYR192
E	HOH223

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 09Q F 211

Chain	Residue
F	TYR89
F	TRP143
F	TYR185
F	CYS188
F	TYR192
G	GLN73
G	ARG104
G	LEU112
G	MET114
G	HOH225

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 09Q G 211

Chain	Residue
G	TYR89
G	TRP143
G	TYR185
G	TYR192
G	HOH259
H	GLN73
H	ARG104
H	LEU112
H	MET114

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 212

Chain	Residue
G	ARG148
H	ARG3
H	PRO71
H	ASP72
H	HOH219

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 09Q H 211

Chain	Residue
H	TYR89
H	SER142
H	TRP143
H	TYR185
H	TYR192
H	09Q213
I	TRP53
I	GLN73
I	ARG104
I	MET114
I	HOH221

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 09Q H 212

Chain	Residue
H	VAL183
H	THR184
H	TYR185
H	HOH795
I	ILE36
I	TRP53
I	TYR164
H	TRP143

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 09Q H 213

Chain	Residue
H	CYS187
H	CYS188
H	09Q211
I	TRP53
I	GLU110
I	LEU112
I	MET114

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 09Q I 211

Chain	Residue
I	TYR89
I	TRP143
I	THR144
I	TYR185
I	TYR192
J	GLN73
J	ARG104
J	LEU112
J	MET114
J	HOH398

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 09Q J 211

Chain	Residue
F	GLN73
F	ARG104
F	LEU112
F	MET114
F	HOH215
J	TYR89
J	TRP143
J	TYR185
J	TYR192

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	206
Details	Domain: {"description":"Ig-like"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)