Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0032045 | cellular_component | guanyl-nucleotide exchange factor complex |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0097216 | molecular_function | guanosine tetraphosphate binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0032045 | cellular_component | guanyl-nucleotide exchange factor complex |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | THR25 |
| A | GDP402 |
| A | HOH503 |
| A | HOH514 |
| A | HOH517 |
| A | HOH531 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GDP A 402 |
| Chain | Residue |
| A | LYS24 |
| A | THR25 |
| A | THR26 |
| A | ASN135 |
| A | LYS136 |
| A | ASP138 |
| A | MET139 |
| A | SER173 |
| A | ALA174 |
| A | LEU175 |
| A | MG401 |
| A | HOH514 |
| A | HOH517 |
| A | HOH554 |
| A | HOH562 |
| A | ASP21 |
| A | HIS22 |
| A | GLY23 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE GDP B 401 |
| Chain | Residue |
| B | HIS19 |
| B | ASP21 |
| B | HIS22 |
| B | GLY23 |
| B | LYS24 |
| B | THR25 |
| B | THR26 |
| B | ASN135 |
| B | LYS136 |
| B | ASP138 |
| B | MET139 |
| B | SER173 |
| B | ALA174 |
| B | LEU175 |
| B | MG402 |
| B | HOH505 |
| B | HOH509 |
| B | HOH512 |
| B | HOH514 |
| B | HOH515 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 402 |
| Chain | Residue |
| B | THR25 |
| B | GDP401 |
| B | HOH505 |
| B | HOH512 |
| B | HOH514 |
| B | HOH516 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN C OF NVP-LDI028 |
| Chain | Residue |
| B | GLU143 |
| B | GLU215 |
| B | ASP216 |
| B | PHE218 |
| B | VAL226 |
| B | THR228 |
| B | THR256 |
| B | GLY257 |
| B | GLU259 |
| B | PHE261 |
| B | ARG262 |
| B | ARG269 |
| B | ASN273 |
| B | VAL274 |
| B | GLY275 |
| B | LEU277 |
| C | HOH101 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN D OF NVP-LDI028 |
| Chain | Residue |
| A | GLU143 |
| A | ILE206 |
| A | GLU215 |
| A | ASP216 |
| A | PHE218 |
| A | THR228 |
| A | THR256 |
| A | GLY257 |
| A | GLU259 |
| A | MET260 |
| A | PHE261 |
| A | ARG262 |
| A | ARG269 |
| A | ASN273 |
| A | VAL274 |
| A | GLY275 |
| A | LEU277 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DNapeEKaRGITIntS |
| Chain | Residue | Details |
| A | ASP50-SER65 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| C | MEN3 | |
| D | MEN3 | |
| A | ASN135 | |
| B | GLY18 | |
| B | ASP80 | |
| B | ASN135 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: 3-hydroxyphenylalanine => ECO:0000250 |
| Chain | Residue | Details |
| C | BB88 | |
| D | BB88 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CROSSLNK: Thiazole-4-carboxylic acid (Ser-Cys) |
| Chain | Residue | Details |
| C | SER1 | |
| C | MH611 | |
| C | BB92 | |
| C | 8BB12 | |
| D | SER1 | |
| D | MH611 | |
| D | BB92 | |
| D | 8BB12 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CROSSLNK: Thiazole-4-carboxylic acid (Cys-Cys) |
| Chain | Residue | Details |
| C | BB910 | |
| C | BB99 | |
| D | BB910 | |
| D | BB99 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CROSSLNK: 5-methylthiazole-4-carboxylic acid (Asn-Cys) |
| Chain | Residue | Details |
| C | MEN3 | |
| C | BB64 | |
| D | MEN3 | |
| D | BB64 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: 5-(methoxymethyl)thiazole-4-carboxylic acid (Val-Cys) |
| Chain | Residue | Details |
| C | VAL5 | |
| C | BB76 | |
| D | VAL5 | |
| D | BB76 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Thiazole-4-carboxylic acid (Phe-Cys) |
| Chain | Residue | Details |
| C | BB88 | |
| D | BB88 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 535 |
| Chain | Residue | Details |
| A | ASP21 | electrostatic stabiliser |
| A | LYS24 | electrostatic stabiliser |
| A | THR25 | metal ligand |
| A | HIS84 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 535 |
| Chain | Residue | Details |
| B | ASP21 | electrostatic stabiliser |
| B | LYS24 | electrostatic stabiliser |
| B | THR25 | metal ligand |
| B | HIS84 | electrostatic stabiliser |
