3U5P
Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-28)K9me3K14acK18acK23ac histone peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| I | 0000786 | cellular_component | nucleosome |
| I | 0003677 | molecular_function | DNA binding |
| I | 0030527 | molecular_function | structural constituent of chromatin |
| I | 0046982 | molecular_function | protein heterodimerization activity |
| J | 0000786 | cellular_component | nucleosome |
| J | 0003677 | molecular_function | DNA binding |
| J | 0030527 | molecular_function | structural constituent of chromatin |
| J | 0046982 | molecular_function | protein heterodimerization activity |
| K | 0000786 | cellular_component | nucleosome |
| K | 0003677 | molecular_function | DNA binding |
| K | 0030527 | molecular_function | structural constituent of chromatin |
| K | 0046982 | molecular_function | protein heterodimerization activity |
| L | 0000786 | cellular_component | nucleosome |
| L | 0003677 | molecular_function | DNA binding |
| L | 0030527 | molecular_function | structural constituent of chromatin |
| L | 0046982 | molecular_function | protein heterodimerization activity |
| M | 0000786 | cellular_component | nucleosome |
| M | 0003677 | molecular_function | DNA binding |
| M | 0030527 | molecular_function | structural constituent of chromatin |
| M | 0046982 | molecular_function | protein heterodimerization activity |
| N | 0000786 | cellular_component | nucleosome |
| N | 0003677 | molecular_function | DNA binding |
| N | 0030527 | molecular_function | structural constituent of chromatin |
| N | 0046982 | molecular_function | protein heterodimerization activity |
| O | 0000786 | cellular_component | nucleosome |
| O | 0003677 | molecular_function | DNA binding |
| O | 0030527 | molecular_function | structural constituent of chromatin |
| O | 0046982 | molecular_function | protein heterodimerization activity |
| P | 0000786 | cellular_component | nucleosome |
| P | 0003677 | molecular_function | DNA binding |
| P | 0030527 | molecular_function | structural constituent of chromatin |
| P | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | CYS890 |
| A | CYS893 |
| A | HIS910 |
| A | CYS913 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 2 |
| Chain | Residue |
| A | CYS902 |
| A | CYS905 |
| A | CYS928 |
| A | CYS931 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | CYS893 |
| B | HIS910 |
| B | CYS913 |
| B | CYS890 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2 |
| Chain | Residue |
| B | CYS902 |
| B | CYS905 |
| B | CYS928 |
| B | CYS931 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1 |
| Chain | Residue |
| C | CYS890 |
| C | CYS893 |
| C | HIS910 |
| C | CYS913 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 2 |
| Chain | Residue |
| C | CYS902 |
| C | CYS905 |
| C | CYS928 |
| C | CYS931 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1 |
| Chain | Residue |
| D | CYS890 |
| D | CYS893 |
| D | HIS910 |
| D | CYS913 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 2 |
| Chain | Residue |
| D | CYS902 |
| D | CYS905 |
| D | CYS928 |
| D | CYS931 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 1 |
| Chain | Residue |
| E | CYS890 |
| E | CYS893 |
| E | HIS910 |
| E | CYS913 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 2 |
| Chain | Residue |
| E | CYS902 |
| E | CYS905 |
| E | CYS928 |
| E | CYS931 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 1 |
| Chain | Residue |
| F | CYS890 |
| F | CYS893 |
| F | HIS910 |
| F | CYS913 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 2 |
| Chain | Residue |
| F | CYS902 |
| F | CYS905 |
| F | CYS928 |
| F | CYS931 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN G 1 |
| Chain | Residue |
| G | CYS890 |
| G | CYS893 |
| G | HIS910 |
| G | CYS913 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN G 2 |
| Chain | Residue |
| G | CYS902 |
| G | CYS905 |
| G | CYS928 |
| G | CYS931 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN H 1 |
| Chain | Residue |
| H | CYS890 |
| H | CYS893 |
| H | HIS910 |
| H | CYS913 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN H 2 |
| Chain | Residue |
| H | CYS902 |
| H | CYS905 |
| H | CYS928 |
| H | CYS931 |
Functional Information from PROSITE/UniProt
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| I | ALY14-LEU20 |
| site_id | PS01359 |
| Number of Residues | 42 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CavCqnggdl.......................................LcCek..Cpkv.FHltChvptllsfpsgd.................................WiCtfC |
| Chain | Residue | Details |
| A | CYS890-CYS931 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| I | ARG2 | |
| J | ARG2 | |
| K | ARG2 | |
| L | ARG2 | |
| M | ARG2 | |
| N | ARG2 | |
| O | ARG2 | |
| P | ARG2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692 |
| Chain | Residue | Details |
| I | THR3 | |
| J | THR3 | |
| K | THR3 | |
| L | THR3 | |
| M | THR3 | |
| N | THR3 | |
| O | THR3 | |
| P | THR3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| I | LYS4 | |
| J | LYS4 | |
| K | LYS4 | |
| L | LYS4 | |
| M | LYS4 | |
| N | LYS4 | |
| O | LYS4 | |
| P | LYS4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| I | GLN5 | |
| J | GLN5 | |
| K | GLN5 | |
| L | GLN5 | |
| M | GLN5 | |
| N | GLN5 | |
| O | GLN5 | |
| P | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| I | THR6 | |
| J | THR6 | |
| K | THR6 | |
| L | THR6 | |
| M | THR6 | |
| N | THR6 | |
| O | THR6 | |
| P | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| I | ARG8 | |
| J | ARG8 | |
| K | ARG8 | |
| L | ARG8 | |
| M | ARG8 | |
| N | ARG8 | |
| O | ARG8 | |
| P | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| I | M3L9 | |
| E | LYS1057 | |
| F | LYS1057 | |
| G | LYS1057 | |
| H | LYS1057 | |
| J | M3L9 | |
| K | M3L9 | |
| L | M3L9 | |
| M | M3L9 | |
| N | M3L9 | |
| O | M3L9 | |
| P | M3L9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| I | SER10 | |
| J | SER10 | |
| K | SER10 | |
| L | SER10 | |
| M | SER10 | |
| N | SER10 | |
| O | SER10 | |
| P | SER10 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| I | THR11 | |
| J | THR11 | |
| K | THR11 | |
| L | THR11 | |
| M | THR11 | |
| N | THR11 | |
| O | THR11 | |
| P | THR11 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| I | ALY14 | |
| J | ALY14 | |
| K | ALY14 | |
| L | ALY14 | |
| M | ALY14 | |
| N | ALY14 | |
| O | ALY14 | |
| P | ALY14 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| I | ARG17 | |
| J | ARG17 | |
| K | ARG17 | |
| L | ARG17 | |
| M | ARG17 | |
| N | ARG17 | |
| O | ARG17 | |
| P | ARG17 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| I | ALY18 | |
| J | ALY18 | |
| K | ALY18 | |
| L | ALY18 | |
| M | ALY18 | |
| N | ALY18 | |
| O | ALY18 | |
| P | ALY18 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| I | ALY23 | |
| J | ALY23 | |
| K | ALY23 | |
| L | ALY23 | |
| M | ALY23 | |
| N | ALY23 | |
| O | ALY23 | |
| P | ALY23 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| I | ARG26 | |
| J | ARG26 | |
| K | ARG26 | |
| L | ARG26 | |
| M | ARG26 | |
| N | ARG26 | |
| O | ARG26 | |
| P | ARG26 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| I | LYS27 | |
| J | LYS27 | |
| K | LYS27 | |
| L | LYS27 | |
| M | LYS27 | |
| N | LYS27 | |
| O | LYS27 | |
| P | LYS27 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| I | SER28 | |
| J | SER28 | |
| K | SER28 | |
| L | SER28 | |
| M | SER28 | |
| N | SER28 | |
| O | SER28 | |
| P | SER28 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 8 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| I | ALY18 | |
| J | ALY18 | |
| K | ALY18 | |
| L | ALY18 | |
| M | ALY18 | |
| N | ALY18 | |
| O | ALY18 | |
| P | ALY18 |
