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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3U5M

Crystal structure of TRIM33 PHD-Bromo in the free state

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS890
A	CYS893
A	HIS910
A	CYS913

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS902
A	CYS905
A	CYS928
A	CYS931

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 3

Chain	Residue
J	ASP898
A	ASP1022

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	CYS890
B	CYS893
B	HIS910
B	CYS913

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	CYS902
B	CYS905
B	CYS928
B	CYS931

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 3

Chain	Residue
B	ASP1022
K	ASP898

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	CYS890
C	CYS893
C	HIS910
C	CYS913

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2

Chain	Residue
C	CYS902
C	CYS905
C	CYS928
C	CYS931

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA C 3

Chain	Residue
C	ASP1022
D	ASP898

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1

Chain	Residue
D	CYS890
D	CYS893
D	HIS910
D	CYS913

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 2

Chain	Residue
D	CYS902
D	CYS905
D	CYS928
D	CYS931

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA E 3

Chain	Residue
D	ASP1022
E	ASP898

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	CYS890
E	CYS893
E	HIS910
E	CYS913

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 2

Chain	Residue
E	CYS902
E	CYS905
E	CYS928
E	CYS931

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA E 1088

Chain	Residue
E	ASP1022
G	ASP898

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1

Chain	Residue
F	CYS890
F	CYS893
F	HIS910
F	CYS913

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 2

Chain	Residue
F	CYS902
F	CYS905
F	CYS928
F	CYS931

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA F 3

Chain	Residue
F	ASP1022
H	ASP898

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 1

Chain	Residue
G	CYS890
G	CYS893
G	HIS910
G	CYS913

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 2

Chain	Residue
G	CYS902
G	CYS905
G	CYS928
G	CYS931

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA F 1088

Chain	Residue
F	ASP898
G	ASP1022

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 1

Chain	Residue
H	CYS890
H	CYS893
H	HIS910
H	CYS913

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 2

Chain	Residue
H	CYS902
H	CYS905
H	CYS928
H	CYS931

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA C 1088

Chain	Residue
C	ASP898
H	ASP1022

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 1

Chain	Residue
I	CYS890
I	CYS893
I	HIS910
I	CYS913

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 2

Chain	Residue
I	CYS902
I	CYS905
I	CYS928
I	CYS931

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA I 3

Chain	Residue
I	ASP1022
L	ASP898

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 1

Chain	Residue
J	CYS890
J	CYS893
J	HIS910
J	CYS913

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 2

Chain	Residue
J	CYS902
J	CYS905
J	CYS928
J	CYS931

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 1088

Chain	Residue
J	ASP1022
B	ASP898

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 1

Chain	Residue
K	CYS890
K	CYS893
K	HIS910
K	CYS913

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 2

Chain	Residue
K	CYS902
K	CYS905
K	CYS928
K	CYS931

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA I 1088

Chain	Residue
I	ASP898
K	ASP1022

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 1

Chain	Residue
L	CYS890
L	CYS893
L	HIS910
L	CYS913

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 2

Chain	Residue
L	CYS902
L	CYS905
L	CYS928
L	CYS931

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 1088

Chain	Residue
A	ASP898
L	ASP1022

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	42
Details	ZF_PHD_1 Zinc finger PHD-type signature. CavCqnggdl.......................................LcCek..Cpkv.FHltChvptllsfpsgd.................................WiCtfC

Chain	Residue	Details
A	CYS890-CYS931

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	564
Details	ZN_FING: PHD-type => ECO:0000255\|PROSITE-ProRule:PRU00146

Chain	Residue	Details
B	GLU887-ILE934
C	GLU887-ILE934
D	GLU887-ILE934
E	GLU887-ILE934
F	GLU887-ILE934
G	GLU887-ILE934
H	GLU887-ILE934
I	GLU887-ILE934
J	GLU887-ILE934
K	GLU887-ILE934
L	GLU887-ILE934
A	GLU887-ILE934

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Breakpoint for translocation to form TRIM33-RET oncogene

Chain	Residue	Details
A	ARG964
B	ARG964
C	ARG964
D	ARG964
E	ARG964
F	ARG964
G	ARG964
H	ARG964
I	ARG964
J	ARG964
K	ARG964
L	ARG964

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q99PP7

Chain	Residue	Details
A	LYS951
B	LYS951
C	LYS951
D	LYS951
E	LYS951
F	LYS951
G	LYS951
H	LYS951
I	LYS951
J	LYS951
K	LYS951
L	LYS951

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS953
B	LYS953
C	LYS953
D	LYS953
E	LYS953
F	LYS953
G	LYS953
H	LYS953
I	LYS953
J	LYS953
K	LYS953
L	LYS953

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	THR1051
B	THR1051
C	THR1051
D	THR1051
E	THR1051
F	THR1051
G	THR1051
H	THR1051
I	THR1051
J	THR1051
K	THR1051
L	THR1051

site_id	SWS_FT_FI6
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:25218447, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS953
B	LYS953
C	LYS953
D	LYS953
E	LYS953
F	LYS953
G	LYS953
H	LYS953
I	LYS953
J	LYS953
K	LYS953
L	LYS953

site_id	SWS_FT_FI7
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:25218447, ECO:0007744\|PubMed:25755297, ECO:0007744\|PubMed:25772364, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
I	LYS1057
J	LYS1057
K	LYS1057
L	LYS1057
A	LYS1057
B	LYS1057
C	LYS1057
D	LYS1057
E	LYS1057
F	LYS1057
G	LYS1057
H	LYS1057

site_id	SWS_FT_FI8
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:25218447

Chain	Residue	Details
A	LYS1007
B	LYS1007
C	LYS1007
D	LYS1007
E	LYS1007
F	LYS1007
G	LYS1007
H	LYS1007
I	LYS1007
J	LYS1007
K	LYS1007
L	LYS1007

site_id	SWS_FT_FI9
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS1043
B	LYS1043
C	LYS1043
D	LYS1043
E	LYS1043
F	LYS1043
G	LYS1043
H	LYS1043
I	LYS1043
J	LYS1043
K	LYS1043
L	LYS1043

221051

PDB entries from 2024-06-12

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