3U5M

Crystal structure of TRIM33 PHD-Bromo in the free state

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS890
A	CYS893
A	HIS910
A	CYS913

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS902
A	CYS905
A	CYS928
A	CYS931

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 3

Chain	Residue
J	ASP898
A	ASP1022

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	CYS890
B	CYS893
B	HIS910
B	CYS913

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	CYS902
B	CYS905
B	CYS928
B	CYS931

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 3

Chain	Residue
B	ASP1022
K	ASP898

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	CYS890
C	CYS893
C	HIS910
C	CYS913

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2

Chain	Residue
C	CYS902
C	CYS905
C	CYS928
C	CYS931

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA C 3

Chain	Residue
C	ASP1022
D	ASP898

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1

Chain	Residue
D	CYS890
D	CYS893
D	HIS910
D	CYS913

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 2

Chain	Residue
D	CYS902
D	CYS905
D	CYS928
D	CYS931

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA E 3

Chain	Residue
D	ASP1022
E	ASP898

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	CYS890
E	CYS893
E	HIS910
E	CYS913

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 2

Chain	Residue
E	CYS902
E	CYS905
E	CYS928
E	CYS931

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA E 1088

Chain	Residue
E	ASP1022
G	ASP898

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1

Chain	Residue
F	CYS890
F	CYS893
F	HIS910
F	CYS913

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 2

Chain	Residue
F	CYS902
F	CYS905
F	CYS928
F	CYS931

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA F 3

Chain	Residue
F	ASP1022
H	ASP898

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 1

Chain	Residue
G	CYS890
G	CYS893
G	HIS910
G	CYS913

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 2

Chain	Residue
G	CYS902
G	CYS905
G	CYS928
G	CYS931

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA F 1088

Chain	Residue
F	ASP898
G	ASP1022

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 1

Chain	Residue
H	CYS890
H	CYS893
H	HIS910
H	CYS913

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 2

Chain	Residue
H	CYS902
H	CYS905
H	CYS928
H	CYS931

---

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA C 1088

Chain	Residue
C	ASP898
H	ASP1022

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 1

Chain	Residue
I	CYS890
I	CYS893
I	HIS910
I	CYS913

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 2

Chain	Residue
I	CYS902
I	CYS905
I	CYS928
I	CYS931

---

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA I 3

Chain	Residue
I	ASP1022
L	ASP898

---

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 1

Chain	Residue
J	CYS890
J	CYS893
J	HIS910
J	CYS913

---

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 2

Chain	Residue
J	CYS902
J	CYS905
J	CYS928
J	CYS931

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 1088

Chain	Residue
J	ASP1022
B	ASP898

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 1

Chain	Residue
K	CYS890
K	CYS893
K	HIS910
K	CYS913

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 2

Chain	Residue
K	CYS902
K	CYS905
K	CYS928
K	CYS931

---

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA I 1088

Chain	Residue
I	ASP898
K	ASP1022

---

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 1

Chain	Residue
L	CYS890
L	CYS893
L	HIS910
L	CYS913

---

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 2

Chain	Residue
L	CYS902
L	CYS905
L	CYS928
L	CYS931

---

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 1088

Chain	Residue
A	ASP898
L	ASP1022

---

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	42
Details	ZF_PHD_1 Zinc finger PHD-type signature. CavCqnggdl.......................................LcCek..Cpkv.FHltChvptllsfpsgd.................................WiCtfC

Chain	Residue	Details
A	CYS890-CYS931

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	564
Details	Zinc finger: {"description":"PHD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Site: {"description":"Breakpoint for translocation to form TRIM33-RET oncogene"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	13
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	22
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---